from the German Breast Group (GBG44) randomly assigned 1,948 patients to receive neoadjuvant epirubicin and cyclophospha-mide followed by docetaxel with or without Avastin. In the Avastin group, PCR was 18.4%, compared with 14.9% in the non-Avastin arm. The other study, dubbed NSABP B-40, randomly assigned 1,206 patients to receive neoadjuvant docetaxel-based chemo-therapy with or without Avast...

Avastin® (bevacizumab) is a protein drug widely used for cancer treatment although its further use is questionable due to serious side effects reported. As no systematic proteomic study on posttranslational modifications (PTMs) was reported so far, it was the aim of the current study to use a gel-based proteomics method for determination of Avastin®-protein(s). Avastin® was run on two-dimension...

BACKGROUND Double-blinded, randomised, prospective, pilot-study to determine the effect of systemic bevacizumab therapy. METHODS Subjects with fibrovascular pigment epithelial detachment, subfoveal choroidal neovascularisation extending under the geometric centre of the foveal avascular zone and/or macular thickness of at least 300 microm in both eyes were included. Sixteen eyes were included...

1. Bevacizumab Not Helpful for Stage III Colorectal Cancer 2. Screening for KRAS and BRAF Mutations 3. Aspirin May Help Older Colon Cancer Patients Live Longer 4. Hypertension Means Better Survival When Treated with Avastin 5. Reduced Risk of Colorectal Cancer With Use of Oral Bisphosphonates 6. Xelox and Avastin Followed by Single Agent Avastin as Maintenance Therapy in First Line Treatment of...

Choroidal neovascularisation is a potentially visually devastating element of various forms of eye pathology. Recent research has focused on neurovascular age-related macular degeneration (AMD) as a cause. AMD can be classified as being exudative (wet) or atrophic (dry). Wet AMD is characterised by a pathological process in which new blood vessels develop in the choroids, causing leakage of flu...

Vascular endothelial growth factor (VEGF) is directly related to cancer and its distant spread, thus, it considered a promising biomarker for diagnosis post-treatment monitoring of patients with malignancies. Zinc protoporphyrin (ZnPP) zinc-centered raw purple compound (protoporphyrin) that has unique optical electrochemical characteristics. In this study, we used ZnPP-modified gold electrode g...