Although vincristine sulfate is indicated for IV use only, it has been inadvertently administered intrathecally. Accidental vincristine administration via the spinal route (intrathecally via a lumbar puncture or intraventricularly via an Ommaya reservoir) causes rapid sensory and motor dysfunction, usually followed by encephalopathy, coma, and death (Schulmeister, 2004). Autopsy fi ndings inclu...

Sporadic Creutzfeldt-Jacob disease (CJD) is a rare fatal neurodegenerative prion disease. Clinical fi ndings of CJD consist of a rapid onset dementia, myoclonus, and neurologic disorders. Defi nitive diagnosis is established with histopathologic confi rmation of brain parenchyma or autopsy materials. Periodic triphasic electroencephalography (EEG) changes and detection of 14-3-3 protein in cere...

J.V. Llau (ed.), Thromboembolism in Orthopedic Surgery, DOI 10.1007/978-1-4471-4336-9_2, © Springer-Verlag London 2013 Abstract Venous thromboembolic disease in hospitalized patients results in substantial mortality, morbidity, and healthcare resource use. While the true incidence of venous thromboembolism (VTE) is dif fi cult to determine, autopsy studies have shown that 5–10 % of hospital dea...

investigative dissection of a dead body primarily to find out cause of death is known as postmortem examination or necropsy. medicolegal autopsy or forensic autopsy is performed following instructions of legal authority in sudden, suspicious, obscure, unnatural or criminal deaths. autopsies are of two types i.e. medico legal autopsy and pathological or hospital autopsy. traditional procedures o...

background: latent adenocarcinoma of prostate refers to cases who present no obvious sign or symptom during their life spans and the tumor is incidentally found at postmortem examination. its frequency can be very important in epidemiologic investigations, prevention and treatment. no previous study has been done in this regard in iran and the studies performed in other countries show various r...

background and objective: ischemic heart disease (ihd) following atherosclerosis is the most common cause of cardiac deaths world wide. we aimed to investigate the pathologic features of atherosclerosis in non cardiac death cases to have an estimate of atherosclerosis prevalence in mashad (north east of iran). patients and methods : this descriptive (cross sectional) study was done, during octo...

Neurological Institute, Columbia University, New York, N.Y. , USA tremities compatible with multifocal myoclonus in the setting of coma. Small (2 mm) poorly reactive pupils, absent corneal refl exes, absent oculocephalic refl exes and fl accid tetraplegia were also noted. An initial CT scan done within 3 h of onset did not reveal signs of intracranial hemorrhage or brain edema, and the brainste...