In Situ Cartilage Repair article 2201588 by Xiong Shu, Sujun Wu, Juan Guan, and co-workers, a cell-free silk protein sponge is fitted on site of cartilage defect. The in situ repair assisted programmed factors E7 TGF-β1, that trigger serial events autologous stem cell homing, directed differentiation chondrocyte proliferation.

INTRODUCTION Matrix-assisted autologous chondrocyte implantation is a well-known procedure for the treatment of cartilage defects, which aims to establish a regenerative milieu and restore hyaline cartilage. However, much less is known about third-generation autologous chondrocyte implantation application in high-level athletes. We report on the two-year follow-up outcome after matrix-assisted ...

Optical reflection spectra of the cartilage/bone interface from hip joints of cows were studied. When comparing to ultrasonic measurement, it was found that cartilage thickness could be extracted using optical reflectance spectroscopy. For thicker cartilage layers, a high reflection for the wavelengths 400-600 was seen, and for thinner cartilage layers, the characteristic spectra of blood and b...

Minced articular cartilage procedures are attractive surgical approaches for repairing articular cartilage, as they are 1-staged, autologous, and inserted on a carrier that can potentially be placed arthroscopically. The principle of mincing the autologous donor cartilage is to create a larger surface area for cartilage expansion. Placement on a scaffold carrier allows for a chondro-inductive a...

BACKGROUND First-generation autologous chondrocyte implantation has limitations, and introducing new effective cell sources can improve cartilage repair. PURPOSE This study was conducted to compare the clinical outcomes of patients treated with first-generation autologous chondrocyte implantation to patients treated with autologous bone marrow-derived mesenchymal stem cells (BMSCs). STUDY D...

INTRODUCTION Third generation autologous chondrocyte implantation (ACI) is a suitable method for the treatment of cartilage defects in the knee joint. However, knowledge about the development of graft thickness and the clinical relevance of incomplete defect filling in the postoperative course is low. This prospective study analyses the graft integration into the surrounding cartilage, with spe...

OBJECTIVE To describe the aesthetic and clinical outcomes following rhinoplasty using autologous costal cartilage, which is considered the best graft material for rhinoplasty requiring major reconstruction. Few studies have examined outcomes following rhinoplasty using autologous costal cartilage. METHODS A retrospective review of the data from 108 patients who underwent rhinoplasty using aut...

Autologous chondrocyte implantation for treatment of isolated cartilage defects of the knee has become well established. Although various publications report technical modifications, clinical results, and cell-related issues, little is known about appropriate and optimal rehabilitation after autologous chondrocyte implantation. This article reviews the literature on rehabilitation after autolog...

To compare the ability of the cartilage precursor cells derived from allogenic and autologous bone marrow mesenchymal stem cells (MSCs) respectively seeded onto “two-phase” allogeneic bone matrix gelatin (BMG) for constructing tissue engineered cartilage in the repair of articular cartilage defects and to observe the repairing efficacy of the two composites for providing the basis for the clini...

Objective(s) Articular cartilage tissue defects cannot be repaired by the proliferation of resident chondrocytes. Autologous chondrocyte transplantation (ACT) is a relatively new therapeutic approach to cover full thickness articular cartilage defects by in vitro grown chondrocytes from the joint of a patient. Therefore, we investigated the redifferentiation capability of human chondrocytes ma...