recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. in particular, advances have occurred in our understanding of the autoimmune inner ear disease (aied). in this article, the authors review the different postulated theories in the pathogenesis of this disease. the clinical presentation, the available para-clinical diagnostic to...

Autoimmune hepatitis is (AIH) is a chronic hepatitis that occurs in children and adults of all ages. It is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. It was first described in the 1950s by term of chronic active hepatitis. It has 2 types with different auto antibodies. Diagnosis is based upon serologic and ...

Dementia is defined as significant acquired cognitive impairment in one or more cognitive domains that represents a significant decline from previous baseline and interferes with independence in daily activities. Autoimmune dementia is a term that has been used to describe a steroid-responsive autoimmune disorder characterized by a rapidly progressive dementia with a fluctuating course. Even co...

pemphigoid gestationis (pg) is a rare autoimmune bullous dermatosis of pregnancy usually presents in the second or third trimester. it is characterized by pruritic, urticarial plaques with the development of tense vesicles and bullae within the lesions. pathogenesis of pg is not fully established, however, most patients develop circulating autoantibodies targeting the bullous pemphigoid (bp) 18...

background autoimmune hepatitis (aih) is a form of chronic hepatitis with unclear causative factors and is characterized by immunological and auto-immunological manifestations. several extrahepatic manifestations, such as other autoimmune disorders, are associated with aih. aih with dermatological conditions as the initial manifestation is rare. we report the case of aih in which erythema nodos...

background: interleukin-27 is a heterodimeric cytokine belonging to il-12 and il-23 families, secreted  by antigen presenting cells( apcs ) .the il-27 is composed of 2 subunits: epstein-barr virus induced gene 3 (ebi3) and p28. il-27 is an anti-inflammatory cytokine which has an inhibitory effect on th17 population and suppress the il-17 expression. it is suggested that il-27 could be a potent ...

the first description of an autoimmune encephalitis dates back to 1888, when hermann oppenheim described a patient with neurological symptoms but no underlying brain pathology. the field of autoimmune encephalitides associated with antibodies targeting cell-surface antigens is rapidly expanding and new antibodies are discovered frequently. autoimmune encephalitis is a difficult clinical diagnos...

introduction coexistence of wilson’s disease and autoimmune hepatitis has been rarely reported in english literature. in this group of patients, there exist features of both diseases and laboratory and histopathological studies may be misleading. medical treatment for any of these entities, per se, may result in poor response. therefore, by considering the acute hepatitis resembling wilson’s di...

about 3 decades ago cd6 identified as one of the first antigens expresses on the majority of t cells and a subset of b cells. cd6 regulates cellular adhesion migration across the endothelial and epithelial cells. in recent years researches indicate its role in pathogenesis of autoimmune diseases. many researches have been done in recent years to block cd6 by cd6 mono clonal antibodies, ior-t1 a...