7-con-O-Methylnogarol (7-OMEN), a new analog of the an thracycline antibiotic, nogalamycin, has chemotherapeutic ac tivity in several experimental mouse tumor systems. As part of the preclinical development of 7-OMEN, the cardiotoxic poten tial was evaluated in chronically dosed rabbits. Groups of 4 rabbits were dosed twice weekly i.v. with 11 or 33 mg/sq m/ week for 12 weeks, 110 sq m/mg/week ...

Passwords are widely used for user authentication, and will likely remain in use in the foreseeable future, despite several weaknesses. One important weakness is that human-generated passwords are far from being random, which makes them susceptible to guessing attacks. Understanding the adversaries capabilities for guessing attacks is a fundamental necessity for estimating their impact and advi...

conclusions this paper highlighted the need to exclude csd in children with unexplained symptoms such as prolonged fever, hepatosplenic lesion and osteomyelitis. case presentation we reported a series of seven children with unusual symptoms of csd. in particular, we described the case of a child with ptosis, miosis and enophtalmy, suggesting horner syndrome, associated with cervical lymphadenit...

Neuroleptic malignant syndrome (NMS) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. NMS mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. Although NMS is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drug...

The aim of this paper is to provide an active inference algorithm for anomalous behavior. As a main concept we introduce fuzzy temporal consistency covering set, and put forward a fuzzy temporal selection model based on temporal inference and covering technology. Fuzzy set is used to describe network anomaly behavior omen and character, as well as the relations between behavior omen and charact...

Background: Atypical hemolytic uremic syndrome (aHUS) is a life-threatening and scarce disorder characterized by acute renal failure and disease, non-immune microangiopathic hemolytic anemia and thrombocytopenia, leading to end-stage renal failure or death, and consequently maybe accompanying by extra renal manifestations. Case report: We reported aHUS accompanied by autoimmune hemolytic anemi...

An advanced, multi-dimensional, and massively parallel simulation approach based on quantum mechanical concepts is introduced and its numerical algorithms briefly summarized. It has been implemented in a computer aided design tool called OMEN, specifically dedicated to next generation nanoelectronic devices. OMEN can treat electron, hole, and phonon (thermal) transport in realistically sized ul...