The ATP-binding cassette transporter A1 (ABCA1) is involved in the regulation of cholesterol efflux from cells. Mutations in ABCA1 give rise to familial high-density lipoprotein (HDL) deficiency and Tangier disease, which is characterized by very low levels of HDL in plasma and cholesteryl ester accumulation in tonsils and other reticuloendothelial cells. The mechanism of action of ABCA1 is sti...

Abstract The plant hormone auxin is distributed in the by a sophisticated network of importers and exporters, including members ABCB subclass ATP-binding cassette (ABC) transporters. ABCB-mediated transport controlled Twisted Dwarf1, member FK506-binding protein (FKBP) family. Here, we summarize current knowledge on ABC transporter regulation FKBPs, which seems to be conserved over kingdoms sub...

OBJECTIVE Nifedipine, an L-type calcium channel blocker, protects against the progression of atherosclerosis. We investigated the molecular basis of the antiatherosclerotic effect of nifedipine in macrophages and apolipoprotein E-deficient mice. METHODS AND RESULTS In macrophages, nifedipine increased peroxisome proliferator-activated receptor-gamma (PPARgamma) activity without increasing PPA...

Inhibitory effect of ark shell (Scapharca subcrenata (Lischke, 1869)) proteolytic hydrolysates (ASHs) on oxidized low-density lipoprotein (oxLDL)-induced macrophage foam cell formation was investigated. Two types ASHs were prepared by Alcalase® and pepsin, ASAH (ark shell-Alcalase® hydrolysates), ASPH shell-pepsin hydrolysate). Oil Red O staining results showed that suppressed lipid accumulatio...