نتایج جستجو برای: atll

تعداد نتایج: 284  

Journal: :Acta dermato-venereologica 2013
Hayakazu Sumida Makoto Sugaya Masahiro Kamata Hiraku Suga Tomomitsu Miyagaki Hanako Ohmatsu Hideki Fujita Shinichi Sato

Cutaneous involvement is frequent in adult T-cell leukaemia/lymphoma (ATLL), a peripheral T-cell neoplasm caused by human T-cell lymphotropic virus type I (HTLV-I). Patients with ATLL manifest different types of skin lesions, including nodules, plaques, ulcers, erythroderma and purpura. It has been reported that this type of skin eruption is an independent prognostic factor for ATLL. We report ...

Journal: :Blood 2012
Hiroyoshi Nishikawa Yuka Maeda Takashi Ishida Sacha Gnjatic Eiichi Sato Fumiko Mori Daisuke Sugiyama Asahi Ito Yasuo Fukumori Atae Utsunomiya Hiroshi Inagaki Lloyd J Old Ryuzo Ueda Shimon Sakaguchi

Adult T-cell leukemia/lymphoma (ATLL) is an intractable hematologic malignancy caused by human T-lymphotropic virus type 1 (HTLV-1), which infects approximately 20 million people worldwide. Here, we have explored the possible expression of cancer/testis (CT) antigens by ATLL cells, as CT antigens are widely recognized as ideal targets of cancer immunotherapy against solid tumors. A high percent...

Journal: :The Tohoku journal of experimental medicine 2015
Shigeru Ehara Kei Takahashi Jun Nishida Masataka Uetani Kenjirou Ohashi Takatoshi Aoki

Adult T-cell leukemia-lymphoma (ATLL) is caused by human T-cell lymphotrophic virus I (HTLV-I) infection. Among ATLL cases, 70% of patients present with leukemia and the remaining patients present with lymphoma. Hand osteolysis in the patients with ATLL is considered as paraneoplastic syndrome and caused by parathyroid hormone-related peptide (PTHrP) released from tumor cells. Radiographic feat...

Journal: :Blood 2008
Tomonori Hidaka Shingo Nakahata Kinta Hatakeyama Makoto Hamasaki Kiyoshi Yamashita Takashi Kohno Yasuhito Arai Tomohiko Taki Kazuhiro Nishida Akihiko Okayama Yujiro Asada Ryoji Yamaguchi Hirohito Tsubouchi Jun Yokota Masafumi Taniwaki Yujiro Higashi Kazuhiro Morishita

Adult T-cell leukemia/lymphoma (ATLL) is caused by latent human T-lymphotropic virus-1 (HTLV-1) infection. To clarify the molecular mechanism underlying leukemogenesis after viral infection, we precisely mapped 605 chromosomal breakpoints in 61 ATLL cases by spectral karyotyping and identified frequent chromosomal breakpoints in 10p11, 14q11, and 14q32. Single nucleotide polymorphism (SNP) arra...

Journal: :Blood 1983
Y Yamada

Surface phenotypes of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma (ATLL) were analyzed by using monoclonal antibodies (anti-Leu-1, anti-Leu-2a, anti-Leu-3a, anti-HLA-DR and MAS 036 c), and the effect of leukemic cells on PWM-induced normal B-cell differentiation was also studied. The majority of ATLL cells bear Leu-1 and Leu-3a antigen on cell surface but lack Leu-2a ant...

2015
Koji Kato Koichi Akashi Louis M. Mansky

Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell lymphoma caused by human T-cell leukemia/lymphoma virus type 1 (HTLV-1). ATLL occurs in approximately 3%-5% of HTLV-1 carriers during their lifetime and follows a heterogeneous clinical course. The Shimoyama classification has been frequently used for treatment decisions in ATLL patients, and antiviral therapy has been reportedly prom...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Toshihiko Ishii Takashi Ishida Atae Utsunomiya Atsushi Inagaki Hiroki Yano Hirokazu Komatsu Shinsuke Iida Kazunori Imada Takashi Uchiyama Shiro Akinaga Kenya Shitara Ryuzo Ueda

PURPOSE Adult T-cell leukemia/lymphoma (ATLL) has a very poor prognosis. We have developed the humanized defucosylated anti-CC chemokine receptor 4 (CCR4) monoclonal antibody KW-0761 as a next generation immunotherapeutic agent. The first aim of the present study was to evaluate whether the antitumor activity of KW-0761 would likely be sufficient for therapeutic clinical application against ATL...

Journal: :Hematology & Transfusion International Journal 2023

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive type of non-Hodgkin's lymphoma that can be primary the skin or secondary, caused by Human lymphotropic virus (HTLV-1) infection. The prevalence HTLV-1 infection high in Brazil, however reports ATLL are rare, possibly underdiagnosed and underreported. This paper presents a case report patient coming from south region country with few cited c...

Journal: :Postgraduate medical journal 1992
S R Johnston P J Hammond

Hypercalcaemia occurs in up to 80% of patients with adult T-cell leukaemia-lymphoma (ATLL) associated with human T-cell leukaemia virus-1 infection. Elevated serum levels of 1,25-dihydroxycholecalciferol, implicated in the pathogenesis of hypercalcaemia in lymphoma, and of parathyroid hormone-related protein (PTHrP), which is associated with hypercalcaemia of several solid malignancies, were de...

Journal: :Journal of clinical and experimental hematopathology : JCEH 2012
Shingo Nakahata Kazuhiro Morishita

CADM1/TSLC1 (Cell adhesion molecule 1/Tumor suppressor in lung cancer 1) is a cell adhesion molecule that was originally identified as a tumor suppressor in lung cancer. CADM1/TSLC1 expression is reduced in a variety of cancers via promoter methylation, and this reduction is associated with poor prognosis and enhanced metastatic potential. In contrast, we observed that CADM1/TSLC1 is highly and...

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