BACKGROUND There is some evidence to support the use of acupuncture as an alternative therapy for asthma. However, the mechanisms underlying its effects are not fully understood. We have reported previously that acupuncture has beneficial effects on asthma without changing the concentration of serum cortisol, although endogenous glucocorticoid (GC) plays an important role in regulating immune r...

OBJECTIVE Asthma is an airway complex disease defined by reversible airway narrowing and obstruction, chronic airway inflammation, airway hyperresponsiveness, and tissue remodeling. The purpose of this study was to determine the effect of Brassica napus L. (B. napus) on airway pathologic changes in a rat model of asthma. MATERIALS AND METHODS Twenty-four rats were divided into 4 groups: contr...

Article history: Received on: 09/02/2015 Revised on: 29/03/2015 Accepted on: 07/06/2015 Available online: 28/08/2015 The present study aimed to evaluate the anti-asthmatic activity of the hydro-alcoholic extract of Citrullus colocynths and Cucumis trigonus (Cucurbitaceae) fruits on Ovalbumin induced Asthma in rats. Extracts were prepared with 70% v/v ethanol using cold maceration followed by So...

Purpose: To investigate the effect of Pinellia polysaccharide on airway remodeling in cough-variant asthmatic rats, and involvement PI3K/AKT signal route process.
 Methods: Seventy-five Sprague-Dawley (SD) rats were assigned to 5 groups: blank control, model, low-dose (100 mg/kg), medium-dose (200 mg/kg) high-dose (400 groups, each with 15 rats. Immunoblot assay was employed measure relati...

BACKGROUND Neurokinins (NKs) participate in asthmatic airway inflammation, but the effects of NKs on airway smooth muscle cells (ASMCs) and those of corticosteroids on NKs are unknown. METHODS To investigate the effect of budesonide on substance P (NK-1) receptor (NK-1R) expression in the lung and ASMCs, 45 Wistar rats were randomly divided into three groups: control, asthmatic, and budesonid...

Asthma, an important public health problem, is a common, potentially serious, medical condition in children, adults and pregnant women. The aim of this study to investigate the effects combined use thymoquinone carob on liver tissue oxidative events, following experimental asthma model. 18 male albino wistar rats were divided into 3 groups as: control group, group treated (A+TQ+C). In asthmatic...

objective(s): the effects of curcuma longa (c. longa) and curcumin on total and differential wbc count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. materials and methods: total and differential wbc count in the blood, no2, no3, mda, sod, cat and thiol levels in serum were examined in control, asthma, asthmatic rats treated with c. longa (0.75, 1.50, and 3.00 mg/ml...

Objective: Plantago major (P. major) is one of the medicinal crops in the world which has therapeutic properties for treatment of respiratory and gastrointestinal diseases. Theophylline is commonly used for the treatment of respiratory diseases. In this study, we investigated the protective effects of hydro-alcoholic extract of P. majoron lung in asthmatic male rats. Materials and Methods: 32 m...

BACKGROUND Basic and clinical studies suggest that hypothalamic-pituitary-adrenal (HPA) axis is the neuroendocrine-immune pathway that functionally regulates the chronic inflammatory disease including asthma. Our previous studies showed corresponding changes of cytokines and leukotriene B4 (LTB4) between brain and lung tissues in antigen-challenged asthmatic rats. Here, we investigated how the ...

Abstract Asthma is a respiratory disease with dramatically increasing incidence globally. The present study explored the roles of S-phase kinase-associated protein 2 (SKP2) and forkhead box O3 (FOXO3) in asthma their involvement Krüppel-like factor 15–lipoprotein receptor-related 5 (KLF15–LRP5) axis. SKP2 expression patients OVA-induced asthmatic Sprague Dawley rats was detected by reverse tran...