نتایج جستجو برای: asthmatic activity
تعداد نتایج: 1143340 فیلتر نتایج به سال:
BACKGROUND AND OBJECTIVE Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known. OBJECTIVE To characterize the potential defect in β-agonist induced cAMP in ASM derived from asthmatic in c...
Asthma has been reported to be associated with a reduction in the activity of glutathione peroxidase (GSH-Px), an important antioxidant enzyme. However, the expression of GSH-Px enzyme activity has not previously been investigated in human eosinophils, which are important inflammatory cells involved in asthma. Reverse transcriptase-polymerase chain reaction and Southern blotting demonstrated th...
Background and Aim: Asthma, as the most prevalent disorder of the airways is accompanied with excessive inflammatory, oxidative and apoptotic activity. In asthmatic patients, serum and hair levels of zinc are decreased. Zinc, as an essential micronutrient for human is reported to have anti inflammatory, anti oxidant and anti apoptosis roles. This study was conducted to investigate the effec...
Indian Journal of Natural Products,2021,35,1,25-31.DOI:10.5530/ijnp.2021.1.6Published:February 2021Type:Original ArticleAuthors:Sagar Soundalgekar, Atish Naik, Kirankumar Hullatti, Sunil Jalalpure, Sneha Patil, and Vishakha Parab Gaonkar Author(s) affiliations:Sagar Soundalgekar1, Naik1, Hullatti2,*, Jalalpure1, Patil1, Gaonkar1 1Department Pharmacognosy, KLE College Pharmacy, Belagavi, Academy...
Introduction: Asthma is a chronic inflammatory and reversible airway disease. Modification of lifestyle by increasing obesity prevalence and decreasing physical activity is one of the main cause of its rising prevalence. Patients with asthma have lower fitness than their healthy counterparts. Regular exercise improves fitness in Asthmatic patients and reduces the symptoms of the disease. Hence,...
Article history: Received on: 09/02/2015 Revised on: 29/03/2015 Accepted on: 07/06/2015 Available online: 28/08/2015 The present study aimed to evaluate the anti-asthmatic activity of the hydro-alcoholic extract of Citrullus colocynths and Cucumis trigonus (Cucurbitaceae) fruits on Ovalbumin induced Asthma in rats. Extracts were prepared with 70% v/v ethanol using cold maceration followed by So...
Changes in adenyl cyclase activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Estimation of the leukocyte adenyl cyclase activity was carried out following in vitro stimulation by sodium fluoride (NaF) or metaproternol. The NaF-stimulated adenyl cyclase activity was significantly lower during asthmatic attacks. An oral administration of metaprotereno...
OBJECTIVE To compare paraoxonase activity and changes in oxidative status in asthmatic children and healthy children by determining serum paraoxonase activity and total oxidative status, total antioxidant capacity and lipid hydroperoxidation. METHODS Forty two asthmatic children were compared with 32 healthy children of similar age and sex. To evaluate the paraoxonase and oxidative status, to...
BACKGROUND The role of platelet activating factor (PAF) in asthma remains controversial. The priming effect of PAF on leukotriene B4 (LTB4) release, 5-lipoxygenase activity, and intracellular calcium levels in asthmatic neutrophils was examined. METHODS LTB4 and other lipoxygenase metabolites in neutrophils obtained from 17 asthmatic patients and 15 control subjects were measured by reverse p...
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