purpose: to report the clinical, paraclinical and histopathologic features of eyelid mass lesions in a patient with tuberous sclerosis. case report: a 14 year old boy with a slowly progressive right upper lid mass and history of seizures, mental retardation and multiple skin lesions on the face and body was referred to labbafinejad medical center. cortical tubers and subepandimal nodules were r...

Background: Multiple sclerosis is one of the most debilitating diseases of the central nervous system, which has chronic process. Clinical manifestations of this disease can also affect their daily activities and, as a result, reduce the quality of life in these people. Thus, considering the importance of quality of life in patients with multiple sclerosis, the present study examines the relati...

multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae), are chronic inflammatory demyelinating disorders of central nervous system (cns). while the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. one of the approaches being proposed in eae therapy is neural stem cells (nscs) trans...

BACKGROUND Several controlled studies provide evidence that treatment with interferon beta in patients with a first event suggestive of multiple sclerosis (MS) delays conversion to clinically definite MS (CDMS). Our aim was to determine whether early initiation of treatment with interferon beta prevents development of confirmed disability in MS. METHODS In the initial placebo-controlled phase...

dear editor multiple sclerosis (ms) is the most common inflammatory demyelinating disease of the central nervous system. ms is characterized by dissemination in time and place. dissemination can be clinically (clinically definite multiple sclerosis) or radiologically by magnetic resonance imaging (mri). correct diagnosis of ms needs dissemination both in time and in place and also exclusion of ...

results of all the ms patients, 78 (95.1%) and 21 (25.6%) were positive for anti-vzv and vzv dna, respectively. statistical analysis of the pcr results showed a significant correlation between the abundance of vzv and ms disease (p < 0.001). however, there was no significant correlation between the abundance of anti-vzv antibodies and ms disease by the elisa method. conclusions these results su...

background: intravenous immunoglobulin (ivig) is an established treatment of immune mediated demyelinating neuropathy including guillain-barré syndrome and chronic inflammatory demyelinating polyneuropathy. recent trials suggest its efficacy in treating relapsing- remitting multiple sclerosis. ivig exerts a number of effects, which may be beneficial in treating multiple sclerosis (ms): reductio...

background and purpose: cognitive impairment (ci) is one of the causes of disabilities in multiple sclerosis patients (ms). therefore, early detection and evaluation of cognitive performance is very important in patients with ms. the aim of the present study is to compare montreal cognitive assessment (moca) test and mini mental status exam (mmse) in relapsing remitting (rr) ms patients. method...