Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required ...

abstract   introduction: it is demonstrated that the degree of clinical improvement in   parkinson's disease (pd) achieved by deep brain stimulation (dbs) is largely dependent   on the accuracy of lead placement. in addition, individual variability in the   situation of subthalamic nucleus (stn) is responsible for spatial inter-individual   fluctuations of the real patient's target.  ...

The study of rhythms and oscillations in the brain is gaining attention. While it is unclear exactly what the role of oscillation, synchrony, and rhythm is, it appears increasingly likely that synchrony is related to normal and abnormal brain states and possibly cognition. In this article, we explore the relationship between basal ganglia (BG) synchrony and reinforcement learning. We simulate a...

  Little is known about the results of pallidal deep brain stimulation (DBS) in DYT6 dystonia. This will be the first report of DYT6 dystonia treated with pallidal DBS from Iran. A 21 years old male patient with DYT6 dystonia underwent bilateral deep brain stimulation. The target of DBS was the sensorimotor region of the posteroventralglobuspallidusinternus (GPi). DBS parameters included an amp...

The micromanipulation of objects into 3-dimensional geometries within holographic optical tweezers is carried out using modified Gerchberg-Saxton (GS) and direct binary search (DBS) algorithms to produce the hologram designs. The algorithms calculate sequences of phase holograms, which are implemented using a spatial light modulator, to reconfigure the geometries of optical traps in many planes...

  Abstract   Introduction: It is demonstrated that the degree of clinical improvement in   Parkinson's disease (PD) achieved by deep brain stimulation (DBS) is largely dependent   on the accuracy of lead placement. In addition, individual variability in the   situation of subthalamic nucleus (STN) is responsible for spatial inter-individual   fluctuations of the real patient's target.   Objecti...

OBJECTIVES To evaluate the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on alexithymia, a deficit in affective regulation, comparing patients with Parkinson's disease (PD) submitted to STN-DBS (DBS group) to PD patients not yet treated with STN-DBS (pre-DBS group) and to healthy participants (C group). METHODS We recruited 27 consecutive STN-DBS PD patients, 38 consec...

background and purpose: multiple sclerosis (ms) is a chronic disease that gives rise to a number of unpleasant symptoms that can be difficult to manage by conventional means. there are some aspects of ms-related disability which can be improved by using deep brain stimulation (dbs); particularly movement disorders, such as tremor. the research aim is to study the effect of dbs on ms tremor with...

WHAT IS DBS? ........................................................................................................................................... 2 History of DBS ....................................................................................................................................... 2 Hardware of DBS ............................................................................