Background: The rate of cardiovascular diseases in developing countries is approximately 60% and it is still has an increasing trend. The clinical effectiveness of aspirin in preventing cardiovascular events has been well proven. Although aspirin is an effective and inexpensive drug, its consumption is not equally beneficial for all patients. Many factors can be affective on the efficacy of ant...

although arterialovenous fistulae (avf) is considered to be vital for chronic kidney disease (ckd) patients, but they may cause complications and problems. for instance they may fail soon after their creation. the most important cause of failure in these cases is intrafistula thrombus formation. whereas anti-platelet drugs are not routinely used after fistulae creation, we conducted this study ...

aspirin is an anti-inflammatory drug, peroxyl radical scavenger, and antioxidant agent that inhibits phospholipases, nitric oxide synthetases, and cyclooxygenase enzymes. the existing literature contains no studies on the effects of various doses of aspirin on spinal cord injury (sci). therefore, we sought to investigate the putative effects of aspirin on experimental sci. the weight-drop injur...

background:   objective: to investigate the association between thrombophilia and unexplained recurrent miscarriage and to evaluate the efficacy of anticoagulant treatment.   materials and methods: in this quasi experimental, we enrolled 520 women, who had a history of recurrent miscarriage. two hundred fifty two women with unexplained recurrent miscarriage were assigned to receive aspirin (80 ...

Aspirin eugenol ester (AEE) is a promising drug candidate, which is used for the treatment of inflammation, pain and fever and the prevention of cardiovascular diseases. This study focuses on the effect of AEE on five proteins which are related to inflammation and thrombosis, including cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), C-reactive protein (CRP), prothrombin (FII) and arachidona...

fatigue is recognized as one of the most disabling and frequent symptoms of multiple sclerosis (ms). amantadine appears to have some proven ability to alleviate the fatigue in ms. the aim of this study was to assess the efficacy of co-administration of amantadine and aspirin for the treatment of fatigue in multiple sclerosis. forty-five ambulatory patients aged 20–50 years with a diagnosis of m...

introduction: the present study evaluated morphological changes of ca1 hippocampal neurons following transient bilateral common carotid and permanent left middle cerebral arteries occlusion, also the neuroprotective effects of aspirin i.p injection was inducing assessed after ischemia in male rat. material and methods: in this experiment, 4 groups of animals were used including; control, sham, ...

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Aspirin may have anticancer properties, and can be effective as a novel strategy for the treatment of colorectal cancer (CRC). The aim of this study was to assess the cytotoxic effects of Aspirin drug in CRC cell lines compared with Oxaliplatin drug in vitro. Methods: Cell viability was assessed after treatment of SW742 and SW48...

Resistance to aspirin and its cytotoxicity significantly limits its therapeutic applications. Nano-liposomal encapsulation of aspirin can reduce its cytotoxicity. In this study, aspirin encapsulated nano-liposomes (AS-NL) was prepared and its performance in drug delivery and cytotoxicity was evaluated. The effects of two independent variables including: number of freeze/thawing cycles and conce...