Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune inflammation of the brain parenchyma mediated with autoantibodies against NMDA receptors in neuronal cells. It most common form encephalitides pediatric patients. In this case report, we present a child anti-NMDAR encephalitis, refractory to first-line therapy.

We present a new multistage method to study the N-Methyl-D-Aspartate (NMDA) neuroreceptor starting from reconstruction of its crystallographic structure. Thanks combination Homology Modelling, Molecular Dynamics and Lattice Boltzmann simulations, we analyse allosteric transition NDMA upon ligand binding compute receptor response ionic passage across membrane.

Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown.Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of ...

anti-n-methyl-d-aspartate receptor (anti-nmdar) encephalitis is is most common form ofimmune-mediated encephalitis with prominent neurologic and psychiatric features at disease onset. we describe a 16 years old patient who presented with fever and status epilepticus. his mri sequences was normal. anti-nmdar antibodies were detected in the csf.  mri, ct and other studies didn,t show any tumor.

background: considering that cannabinoids protect neurons against neurodegeneration, in this study, the neuroprotective effect of win55,212-2 in paraoxon induced neurotoxicity in pc12 cells and the role of the n-methyl-d-aspartate (nmda) receptor were evaluated. materials and methods: in this study pc12 cells were maintained in dulbecco's modified eagle’s medium (dmem+f12) culture medium supple...

The D-isomer of aspartate is both a substrate for glutamate transporters and an agonist of N-methyl-D-aspartate (NMDA) receptors. To monitor the behavior of these receptors and transporters in intact tissue we synthesized a new photo-labile analogue of D-aspartate, N-[(6-nitrocoumarin-7-yl)methyl]-D-aspartic acid (Ncm-D-aspartate). This compound was photolyzed rapidly (t(1/2)=0.11 micros) by UV...

Anti-N-Methyl-D-Aspartate Receptor Encephalitis (Anti NMDARE) is an immune mediated encephalitis. It one of the most common cause acute and sub-acute encephalopathy. Clinical features include behavioral disturbances, psychiatric manifestations, seizures, movement disorders [1]. Here we report a case 3 year 1 month old girl who presented with difficulty in walking involuntary movements. There we...