Aspartate aminotransferases have been cloned and expressed from Crithidia fasciculata, Trypanosoma brucei brucei, Giardia intestinalis, and Plasmodium falciparum and have been found to play a role in the final step of methionine regeneration from methylthioadenosine. All five enzymes contain sequence motifs consistent with membership in the Ia subfamily of aminotransferases; the crithidial and ...

In previous studies it was found that: (a) aspartate aminotransferase increases the aspartate dehydrogenase activity of glutamate dehydrogenase; (b) the pyridoxamine-P form of this aminotransferase can form an enzyme-enzyme complex with glutamate dehydrogenase; and (c) the pyridoxamine-P form can be dehydrogenated to the pyridoxal-P form by glutamate dehydrogenase. It was therefore concluded (F...

OBJECTIVES Diabetes mellitus is associated with biochemical, physiological and pathological alterations in the liver. The aim of this study was to investigate the effects of hydroalcoholic extract of Prangos ferulacea (L.) Lindle (P.f) on changes in rats´ liver structure and serum activities of alanin and aspartate aminotransferases after alloxan injection. MATERIALS AND METHODS In this study...

Increased aminotransferases often indicate hepatic injury but are also increased with damage to heart and muscle (1 ). Testing for creatine kinase is helpful, especially when the ratio of aspartate aminotransferase to alanine aminotransferase is 3:1, a value uncommon with liver injury. In acute liver injury the aspartate aminotransferase/alanine aminotransferase ratio is usually 2:1. When measu...

An overdose of tramadol is a frequent reason for hepatic and renal toxicity possible death.Hence, this study aimed at investigating the impact on serum liver enzyme, oxidative stressm som antioxidant markers in male rabitts. Methods: A total 20 growing rabbits (7.5 weeks old) reared under high ambient temperature were divided into two equal groups, 10 each. The first group control administered ...