BACKGROUND Asbestosis is characterized by lung and pleural fibrosis and by immune system dysregulation, with autoantibody production and systemic immune-mediated disease. No specific therapies are available for asbestosis. Recently, the pivotal pathogenic role exerted by interleukin-1beta has been recently reported. CASE PRESENTATION We treated with anti-interleukin 1 beta targeted antibody c...

Asbestosis is the most important change noted in the lung parenchyma after environmental and occupational exposure to asbestos fibers. It is characterized by diffuse interstitial pulmonary fibrosis. In Korea, the incidence of asbestosis will continue to increase for many years to come and the government enacted the Asbestos Damage Relief Law in 2011 to provide compensation to those suffering fr...

The mortality from ischaemic heart disease was studied in a prospective cohort of 1725 shipyard workers exposed to asbestos. The analyses were stratified for age and smoking habits and restricted to men. In agreement with other findings, men with impaired lung function had a significantly higher risk (relative risk (RR) = 3.5) of dying from ischaemic heart disease than men with normal lung func...

Asbestos, a known occupational pollutant, may upregulate the activity of inducible nitric oxide synthase (iNOS) and thus the production of nitric oxide (NO). This study investigated whether iNOS (CCTTT)(n) polymorphism is associated with an increased asbestosis risk in exposed workers. The study cohort consisted of 262 cases with asbestosis and 265 controls with no asbestos-related disease. For...

interstitial fibrosis (asbestosis) and COPD in causing impairment is difficult to ascertain because both will tend to similarly affect commonly used physiologic parameters of impairment; forced vital capacity (FVC); forced expiratory volume in one second (FEy,), diffusing capacity (D), and alveolar-arterial oxygen gradient (P[A-a]O,); however, the total lung capacity (TLC) is affected in opposi...

AIMS To determine if the presence of asbestosis is a prerequisite for lung cancer in subjects with known exposure to blue asbestos (crocidolite). METHODS Former workers and residents of Wittenoom with known amounts of asbestos exposure (duration, intensity, and time since first exposure), current chest x ray and smoking information, participating in a cancer prevention programme (n = 1988) we...

OBJECTIVE To investigate whether asbestosis is a risk factor for mortality of lung cancer. METHODS A fixed cohort study was established in an asbestos plant in Chongqing, China, and followed up for 30 years from the beginning of 1972. Basic personal information on life state, cause of death, and diagnosis of asbestosis was collected. Multiple logistic regressions were applied to analyze risk ...

Asbestos related lesions of the lung parenchyma and the pleura can be divided into three main types: parietal pleural plaques, diffuse interstitial fibrosis ("classical asbestosis"), and a third type of reaction affecting both the pleura and the lung parenchyma. The last type includes such lesions as acute pleurisy, diffuse pleural thickening, and rounded atelectasis. Among 1344 patients with a...

To cite: Tunsupon P, Yampikulsakul P. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015214189 DESCRIPTION A 90-year-old man was referred for evaluation of shortness of breath. He had a significant history of asbestos exposure, dating back to when he removed asbestos insulation from a US Navy ship 60 years earlier. He had quit smoking 30 years prior to presentat...