The pathogenesis of nonalcoholic steatohepatitis (NASH) is poorly defined. Feeding mice a diet deficient in methionine and choline (MCD diet) induces experimental NASH. Osteopontin (OPN) is a Th1 cytokine that plays an important role in several fibroinflammatory diseases. We examined the role of OPN in the development of experimental NASH. A/J mice were fed MCD or control diet for up to 12 wk, ...

Cholestasis, or impaired bile flow, is an important but poorly understood manifestation of liver disease. Two clinically distinct forms of inherited cholestasis, benign recurrent intrahepatic cholestasis (BRIC) and progressive familial intrahepatic cholestasis type 1 (PFIC1), were previously mapped to 18q21. Haplotype analysis narrowed the candidate region for both diseases to the same interval...

Imagine that you get such certain awesome experience and knowledge by only reading a book. How can? It seems to be greater when a book can be the best thing to discover. Books now will appear in printed and soft file collection. One of them is this book innovation happens elsewhere open source as business strategy. It is so usual with the printed books. However, many people sometimes have no sp...

The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Here we show that Rdx( / ) mice are normal at birth, but their serum concentrations of conjugated bilirubin begin to increase gradually around 4 wee...

Abstract This text introduces the symposium on Fredric Jameson’s Allegory and Ideology (2019), second volume in his six-part The Poetics of Social Forms . It frames debate with a brief exploration some figures problems allegory that appear across œuvre , surveys Marxist conceptualisations have shaped approach, as it straddles allegories commodity utopia. musical investigation nexus affect, pres...