The aryltetralin lignan deoxypodophyllotoxin is much more widespread in the plant kingdom than podophyllotoxin. The latter serves as a starting compound for the production of cytostatic drugs like etoposide. A better insight into the occurrence of deoxypodophyllotoxin combined with detailed knowledge of its biosynthestic pathway(s) may help to develop alternative sources for podophyllotoxin. Us...

A novel and efficient procedure to prepare highly oxidised aryltetralin lignans, such as isopodophyllotoxone and (-)-aristologone derivatives, by oxidation of podophyllotoxin and galbulin with methylrhenium trioxide (MTO) and novel MTO heterogeneous catalysts is reported. It is noteworthy that in the case of isopodophyllotoxone derivatives the functionalisation of the C-4 position of the C-ring...

Eight new aryltetralin lignans, cleisindosides A-F (1-6), picroburseranin (7), and 7-hydroxypicropolygamain (8), were isolated from the fruits of Cleistanthus indochinensis (Euphorbiaceae). The structures of the isolates were established on the basis of their one- and two-dimensional NMR spectral data, as well as their mass spectrometric data. Compound 7 was found to have potent cytotoxicity ag...

a procedure was developed for rapid in vitro germination of linum album seeds by scarification and exposing to gibberellic acid (ga3) and kinetin (kn).  concentrations of podophyllotoxin (ptox) and related aryltetralin lignans α-peltatin, β-peltatin, 5’-demethoxy-6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin (mptox) in l. album fresh plant organs were determined by hplc. a degree of var...

Two new aryltetralin-type lignans, isopodophyllotoxin 7'-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (1) and 4-demethyl-picropodophyllotoxin 7'-O-beta-D-glucopyranoside (2), along with eight known podophyllotoxin derivatives: 4-demethyl-podophyllotoxin 7'-O-beta-D-glucopyranoside (3), podophyllotoxin 7'-O-beta-D-glucopyranoside (4), deoxypodophyllotoxin (5), picropodophyllotoxin (6),...

Schisandra chinesis (S. chinesis) is widely used as one of the 50 fundamental herbs in traditional Oriental medicine; the species is a member of the Schisandra genus of shrub, which grows commonly in the native forests of Northern China, Korea, Japan and Russia. The Schisandra are deciduous climbers that thrive in any type of soil, so long as it is moist, shaded, and well-drained (Panossian and...

      A procedure was developed for rapid in vitro germination of Linum album seeds by scarification and exposing to gibberellic acid (GA3) and kinetin (Kn).  Concentrations of podophyllotoxin (PTOX) and related aryltetralin lignans α-peltatin, β-peltatin, 5’-demethoxy-6-methoxypodophyllotoxin and 6-methoxypodophyllotoxin (MPTOX) in L. album fresh plant org...