Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and cell death during G2/M. The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhibitor of ribonucleotide reductase (RNR), causing a severe depletion in cellular dNTP pools. Here, the casual link between the S phase arrest, Sml1,...

The article focuses on arrival of vessel from Kerkyra, Greece carrying dead crew members body died mysterious disease in Messina May 1743 and mentions redoubled quarantine that expresses isolation need collective Topics discussed include possibility writing when solitude started, social distance which strips what remains crisis capitalism, ecology China-U S -Russia strategic relation due to cor...

We report on a campaign of X-ray and soft γ-ray observations of the black hole candidate H 1743-322 (also named IGR J17464-3213), performed with the RXTE, INTEGRAL and Swift satellites. The source was observed during a short outburst between 2008 October 03 and 2008 November 16. The evolution of the hardness-intensity diagram throughout the outburst is peculiar, in that it does not follow the c...

In 1743, Hunter11 described ulcerations of articular cartilage as problems that will not heal. The clinical consequences of articular cartilage knee defects are pain, swelling, mechanical symptoms, athletic and functional disability, and osteoarthritis (Figure 1). Full-thickness articular cartilage defects have a poor capacity to heal. The challenge to restore the articular cartilage surface is...