Protective effect of Hedyotis diffusa (H. diffusa) Willd against lipopolysaccharide (LPS)-induced renal inflammation was evaluated by the productions of cytokines and chemokine, and the bioactive constituents of H. diffusa were detected by the ultra-fast liquid chromatography-diode array detector-quadrupole-time of flight mass spectrometry (UFLC-DAD-Q-TOF-MS/MS) method. As the results showed, w...

Objective To establish the method for quantitative determination of oleanolic acid in Hedyotis diffusa Willd., and study its inhibitory effect on human hepatoma HepG-2 cells. Methods HPLC with a column of Angilent ZORBAX Eclips Plus C18 (4.6 × 250 mm, 5 um) is used; column temperature: 20°C. Detection wavelength: 210nm. Anti-hepatoma activity of Hedyotis diffusa Willd. is analyzed by observing ...

Oldenlandia diffusa has been empirically used as a therapeutic adjunct for the treatment of respiratory infections. To establish the basic evidence of its clinical usefulness, antimicrobial and biofilm inhibitory activities of an O. diffusa extract were examined against clinical isolates of Haemophilus influenzae, a major causative pathogen of respiratory and sensory organ infections. No signif...

Boerhavia diffusa (B. diffusa), also known as Punarnava, is an indigenous plant in India and an important component in traditional Indian medicine. The accurate identification and collection of this medicinal herb is vital to enhance the drug's efficacy and biosafety. In this study, a DNA barcoding technique has been applied to identify and distinguish B. diffusa from its closely-related specie...

BACKGROUND Ayurvedic literature claims that Boerhavia diffusa possesses rejuvenative properties especially related to the urinary system. OBJECTIVE To evaluate effect of aqueous extract of root of Boerhavia diffusa in gentamicin-induced nephrotoxicity in rats. MATERIALS AND METHODS Study was conducted in two parts, using 40 rats in each part. Rats were equally divided into five groups for e...

Hedyotis diffusa Willd (H. diffusa) is a well-known Chinese medicine with a variety of activities, especially its anti-cancer effect in the clinic. Up to now, 171 compounds have been reported from H. diffusa, including 32 iridoids, 26 flavonoids, 24 anthraquinones, 26 phenolics and their derivatives, 50 volatile oils and 13 miscellaneous compounds. In vitro and in vivo studies show these phytoc...

OBJECTIVE To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae; T. diffusa), as well as its toxicity in astrocytes. METHODS Chemical analyses of hydroethanolic extract from powdered aerial parts ofT. diffusa were carried out using HPLC-DAD-ESI-MS/MS.In vitro assays using astrocytes culture were performed to evalu...

Result: In total, 43 components were identified in Hedyotis diffusa Willd. The identified components comprised 11 alcohols, 7 alkenes, 5 ketones, 7 aldehydes, 6 acid substances, 2 esters, 5 other substances. The major components in the Hedyotis diffusa WILLD oil were Hexadecanoic acid (48.89%) followed by Pentadecanoic acid (6.11%), D-Limonene (5.74%) and fatty acid were the most abundant compo...