نتایج جستجو برای: arrhythmogenicity
تعداد نتایج: 246 فیلتر نتایج به سال:
AIMS Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation. Recent work associates reduced atrial Nav 1.5 currents in homozygous RyR2-P2328S (RyR2(S/S) ) mice with slowed conduction and increased arrhythmogenicity. Yet clinically, and in murine models, the Nav...
RATIONALE Myocardial delivery of human mesenchymal stem cells (hMSCs) is an emerging therapy for treating the failing heart. However, the relative effects of hMSC-mediated heterocellular coupling (HC) and paracrine signaling (PS) on human cardiac contractility and arrhythmogenicity remain unresolved. OBJECTIVE The objective is to better understand hMSC PS and HC effects on human cardiac contr...
Brugada syndrome is a primary electrical disorder of the heart, predisposing affected individuals to potentially lethal, ventricular tachy-arrhythmias. A number of mechanisms have been identified as being important increasing the risk of these rhythms. Wavelength (λ) restitution has been suggested to predict the onset of action potential duration (APD) alternans in mouse Scn5a hearts modelling ...
BACKGROUND Pharmacological interventions for prevention of sudden arrhythmic death in patients with chronic heart failure remain limited. Accumulating evidence suggests increased ventricular expression of T-type Ca(2+) channels contributes to the progression of heart failure. The ability of T-type Ca(2+) channel blockade to prevent lethal arrhythmias associated with heart failure has never been...
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