OBJECTIVE To discuss the application of ARMS method to detect EGFR gene mutation in cerebrospinal fluid of lung adenocarcinoma patients with meningeal metastasis. METHODS 5 cases of lung adenocarcinoma were identified with meningeal metastasis that were cleared EGFR gene mutation by gene sequencing method. From each patient 5ml cerebrospinal fluid was obtained by lumbar puncture. ARMS method ...

The muscle-tendon moment arm is an important input parameter for musculoskeletal models. Moment arms change as a function of joint angle and contraction state and depend on the method being employed. The overall purpose was to gain insights into the interactive effects of joint angle, contraction state and method on the Achilles tendon moment arm using the center of rotation (COR) and the tendo...

The inverse kinematics problem of a two degree of freedom (2DOF) planar robot arms issolved using Adomian’s decomposition method (ADM), after converting to a system of twononlinear algebraic equations. The advantage of the method is that it gives the solutions asfunctions of the desired position of the end effecter and the length of the arms. The accuracyof the solutions can be increased up to ...

Quantification of epidermal growth factor receptor (EGFR) mutations is important for the prediction of tyrosine kinase inhibitor (TKI) efficacy in patients with non-small cell lung cancer (NSCLC). However, clinicians lack a sensitive and convenient method to quantify EGFR mutant abundance. The present study introduces a novel method, namely amplification refractory mutation system (ARMS)-Plus, ...

BACKGROUND The tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) is a fast and economical means of assaying SNP's, requiring only PCR amplification and subsequent electrophoresis for the determination of genotypes. To improve the throughput and efficiency of T-ARMS-PCR, we combined T-ARMS-PCR with a chimeric primer-based temperature switch PCR (TSP) strategy, and used capil...

Moment arms represent a muscle's ability to generate a moment about a joint for a given muscle force. The goal of this study was to develop a method to measure muscle moment arms in vivo over a large range of motion using real-time magnetic resonance (MR) imaging. Rectus femoris muscle-tendon lengths and knee joint angles of healthy subjects (N = 4) were measured during dynamic knee joint flexi...

This paper proposes a force control method for the live-working robot. Some live-working task requires larger stiffness such as pushing and butting when replacing cross arm or insulator. Two arms are attached on the live-working robot to meet this requirement and other need for cooperation by two arms. The different kinematic structure of this two arms brings many difficulties to get the dynami...

We present a new method for estimating the corotation radius in tightly wound spiral galaxies, through analysis of the radial variation of the offset between arms traced by the potential (P-arms) and those traced by dust (D-arms). We have verified the predictions of semi-analytical theory through hydrodynamical simulations and have examined the uniqueness of the galactic parameters that can be ...

background inflammatory bowel disease (ibd) is a chronic, relapsing, inflammatory disorder of the gastrointestinal tract that includes two entities, crohn`s disease (cd) and ulcerative colitis (uc). as with other complex diseases, both genetic susceptibility and environmental factors play role in the pathogenesis of these diseases. the tumor necrosis factor α (tnf-α) gene is located in the ibd3...