This paper describes how in vitro efficacy of aptamer-loaded gold nanostars (Apt-AuNS) can be enhanced by the increased loading of a G-quadruplex homodimer AS1411 (Apt) on the AuNS surface. In a low pH buffer environment, the loading density of Apt on AuNS was increased up to 2.5 times that obtained using the conventional salt-aging process. These highly loaded AuNS nanoconstructs (*Apt-AuNS) w...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Overview of APTs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

The present book has the...purpose of straightening thought about war and peace.... [I]t seemed best to refrain from condemnation altogether. For indignation is so easy and satisfying a mood that it is apt to prevent one from attending to any facts that oppose it. If the reader should object that I have abandoned ethics for the false doctrine that “to understand everything is to pardon everythi...

Relation of antiplatelet therapy (APT) discontinuation with the risk of serious cardiovascular events has not been fully addressed yet. This study is aimed to evaluate the risk of ischemic event after APT discontinuation based on long-term APT status of large cohort. In the CREDO-Kyoto Registry Cohort-2 enrolling 15939 consecutive patients undergoing first coronary revascularization, 10470 pati...

Some authors have found a strong statistical association of antibodies to prothrombin (aPT) with thrombosis in patients with antiphospholipid syndrome (APS); others have not confirmed this finding. It is unknown if the detection of aPT, in addition to anticardiolipin (aCL) and anti-beta2-glycoprotein-I (abeta2GP-I) antibodies, provides additional information in the clinical study of these patie...

Food protein-induced enterocolitis syndrome (FPIES) is thought to be a non-IgE mediated food allergy syndrome. Affected infants typically demonstrate gastrointestinal symptoms after hours after ingestion of the offending food. Traditional allergy testing is not useful for this disorder because tests for food specific IgE are routinely negative. A diagnostic oral food challenge (OFC) is the only...

3. Animal knowledge is essentially apt belief, to be distinguished from the more demanding reflective knowledge. This is not to say that the word ‘knows’ is ambiguous. Maybe it is, but distinguishing a kind of knowledge as “animal” knowledge requires no commitment to that linguistic thesis. Indeed it requires no definition of the word ‘knows’ at all. One might take this to be primitive and stil...

BACKGROUND The American Society of Gastrointestinal Endoscopy (ASGE) published updated guidelines in 2009 to help endoscopists manage the treatment of their patients who have been prescribed antiplatelet therapy (APT). STUDY AIM To assess the use of APT among endoscopists, and to identify factors guiding their use of APT while treating their patients. METHOD A survey questionnaire was distr...