At present, only a few drugs have been approved by the FDA for therapy of viral infections in humans. There is a great need for antiviral drugs with increased potency and decreased toxicity, as well as drugs to treat viral diseases for which no drug or vaccine is currently available. Two approaches for development of antiviral drugs are described--an empirical strategy and a rational strategy--...

The early preclinical development of an antiviral agent is accomplished essentially in two stages. The first stage consists of gathering data to estimate the potential therapeutic index of the agent. This process includes testing for antiviral activity and for cytotoxicity in vitro and performing preliminary pharmacokinetic and toxicology studies in vivo. The second stage consists of carrying o...

Antiviral agents have been hailed to hold considerable promise for the treatment and prevention of emerging viral diseases like H5N1 avian influenza and SARS. However, antiviral drugs are not completely harmless, and the conditions under which individuals are willing to participate in a large-scale antiviral drug treatment program are as yet unknown. We provide population dynamical and game the...

We thank all the respondents to the survey and the nurses at the Leicestershire Hospice for their interest and willing participation, Dr Carol Jagger for statistical help, and Miss K Jeffery for preparing the typescript. I St Christopher"s Hospice Iniformation Service. 1988 Direcion, of liospiCe serz.ices. Svdcnliaini: St (hristopher's Hospice, 1988. 2 Hill F, Oliver C. Hospice-thc cost of in-p...

objectives the current research aimed to study achillea millefolium and thymus vulgaris antiviral activity against newcastle disease virus (ndv). materials and methods the antiviral activity of the plants was measured by the reduction assay of viral titer, and explained by inhibition percentage (ip). background nowadays natural products such as pure compounds and plant extract scan provide unli...