Previous pharmacological essays had reported the anti-inflammatory and analgesic activities of Thymus broussonetii extracts. This current study extended these previous works and aimed at investigating the potential antipyretic effect of T. broussonetii. For that, we have tested the effect of aqueous, butanolic and ethyl acetate extracts of T. broussonetii on yeastinduced fever in rats. Our resu...

Activation of central melanocortin receptors (MCR) inhibits fever, but the identity of the MCR subtype(s) mediating this antipyretic effect is unknown. To determine whether selective central melanocortin receptor-4 (MC4R) activation produces antipyretic effects, the MC4R selective agonist MRLOB-0001 (CO-His-d-Phe-Arg-Trp-Dab-NH(2)) was administered intracerebroventricularly to rats treated with...

The antipyretic activity of a herbal formulation, TBR-002 was compared with that of andrographis paniculata, andrographis elongate and paracetamol in yeast-induced pyrexia in male albino rats, TBR-oo2 was found to be effective at an oral dose of 100 mg/kg in the inhibition if pyrexia. Its efficacy was almost comparable to that of paracetamol as well as andrographis elongate, the antipyretic act...

The antipyretic activities of the alcoholic extracts of three species of Andrographis Wall, were assayed at a dose of 500 mg/kg body weight in pyrogenic polysaccharide - induced hyperpyrexia in male albino rats. All the extracts were found to be effective in the inhibition of pyrexia. The maximal antipyretic activity was found with the alcoholic extract of Andrographis alata Nees.

OBJECTIVE The main objective of this work was to study the antipyretic and antibacterial activity of C. erectus (Buch.-Ham.) Verdcourt leaf extract in an experimental albino rat model. MATERIALS AND METHODS The methanol extract of C. erectus leaf (MECEL) was evaluated for its antipyretic potential on normal body temperature and Brewer's yeast-induced pyrexia in albino rat's model. While the a...

There is little doubt that clinicians will continue to seek new and, one hopes, more intelligent ways to suppress fever. In the process, new agents will be developed, new uses will be identified for existing antipyretic agents, new measures will be designed to maximize the benefits of antipyretic therapy while minimizing its adverse effects, and a concerted effort will be made to define more cl...

Fever is among the most common manifestations of disease and antipyresis is one of the most usual therapeutic intervention undertaken. A variety of microbial products including endotoxins and exotoxins are recognized as exogenous pyrogens which induce host cells to produce mediators known as endogenous pyrogens. The best studied endogenous pyrogen is interleukin 1, others include tumor necrosis...

Purpose. The study aimed to investigate the effectiveness of antipyretic therapy on mortality in critically ill patients with sepsis requiring mechanical ventilation. Methods. In this study, we employed the multiparameter intelligent monitoring in intensive care II (MIMIC-II) database (version 2.6). All patients meeting the criteria for sepsis and also receiving mechanical ventilation treatment...

OBJECTIVE This meta-analysis aimed to examine the impact of antipyretic therapy on mortality in critically ill septic adults. DATA SOURCES Literature searches were implemented in Ovid Medline, Embase, Scopus, Cumulative Index of Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, NHS Economic Evaluation Database, and ClinicalTrials.gov through February 2016. ...