normal 0 false false false en-us x-none ar-sa background: cardiovascular diseases, cardiovascular risk factors, and mortality due to these situations are more frequently encountered in schizophrenic patients when compared with the general population. the mean platelet volume (mpv) is a surrogate biomarker of the platelet activity and an useful prognostic test in cardiometabolic diseases. the ai...

There has been significant confusion about the relative advantage of new generation antipsychotics over first generation antipsychotics as well as of clinical trials performed to evaluate their efficacy vs. those designed to evaluate their effectiveness. Pragmatic or effectiveness clinical trials like CATIE and CUtLASS sponsored by governments have challenged the current worldview of the greate...

The effectiveness and safety of antipsychotics have not been fully established in children adolescents. Many approved for use adults are prescribed off-label to We investigated the tolerability adolescents with schizophrenia bipolar disorder. A literature review empirical evidence regarding antipsychotics, particularly second-generation showed that these drugs were safe effective this populatio...

CONTEXT Understanding the association between use of antipsychotics and onset of diabetes. OBJECTIVE To compare the rates of new-onset diabetes mellitus (DM) between patients treated for schizophrenia with atypical or conventional antipsychotics. DESIGN Retrospective analysis of medical and pharmacy claims data. SETTING 61 US health plans. PATIENTS Patients with schizophrenia who were t...

Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal adverse event associated with the use of antipsychotics. Although atypical antipsychotics were initially considered to carry no risk of NMS, reports have accumulated over time implicating them in NMS causation. Almost all atypical antipsychotics have been reported to be associated with NMS. The clinical profile of NMS caused b...

olanzapine, an atypical antipsychotic, is one of the most commonly used antipsychotics. though olanzapine is commonly associated with endocrine side effects, it is generally well tolerated by most patients and is rarely associated with urinary incontinence. this report highlights the case of a 23 -year old male patient with schizophrenia who developed severe urinary incontinence following the u...

Background: Sexual dysfunction (SD) is a common occurrence in Schizophrenia on antipsychotics, both typical and atypical. Indian studies this regard are not many number. Aims Objectives: The aims of study were to investigate SD Schizophrenics Trifluoperazine, Risperidone, Olanzapine also evaluate the incidence relation duration illness, treatment, dosage drugs each group subjects. Materials Met...

BACKGROUND Little is known about the treatment of delusional parasitosis with typical and atypical antipsychotics. AIMS To evaluate the effectiveness of typical and atypical antipsychotics in primary delusional parasitosis (delusional disorder, somatic type). METHOD A systematic review was conducted. RESULTS No randomised trials were found and hence we collected the best evidence from 16 ...

BACKGROUND Second generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation linked to the use of SGAs. The aims of this article are to present patients with a history of psychotic disorders and of severe metabolic diabetic ketoacidosis, possibly associated with the use ...

Neutropenia is a well-known adverse side-effect of clozapine that can also be seen with other atypical antipsychotics. In this article the authors discuss patient who experienced neutropenia and subsequently redeveloped aripiprazole after short trial. The case illustrates close monitoring caution advisable when trialing patients on any further antipsychotics neutropenic event clozapine.