introduction: olanzapine (zyprexa) has become one of the most commonly prescribed atypical antipsychotic drug in iran, at least in part due to its low potential to cause extra-pyramidal side effects. case: a 54-year-old man, who was a known case of schizophrenia from 10 years ago and within the recent years, was under periodic medical treatment by antipsychotic drugs. conclusion: neurologists a...


 For antipsychotic-related sexual dysfunction, 1 guideline recommends switching to aripiprazole or another non-hyperprolactinemic antipsychotic as the first option. Alternatively, adjunctive treatment with aripiprazole, antipsychotics that have less impact on function. Another adding estrogen testosterone medication assist dysfunction in women.
 antidepressant-related agomelatine a n...

INTRODUCTION The aim of this survey is to determine the pattern of antipsychotic drug use in patients with psychotic disorders, living in board and care facilities and to investigate the related factors. METHODS We evaluated the antipsychotic drug use pattern in outpatients with psychotic disorders according to DSM-IV, living in board and care facilities. Patients using polypharmacy at least ...

Priapism is a rare but important side effect of antipsychotic drugs which may evolve into a urological emergency. Most antipsychotic drugs are alpha-1 adrenergic antagonists, which is thought to be the principal mechanism involved in antipsychotic-induced priapism. Other aetiologies exist, however. A case is presented with multiple episodes of priapism during the use of several different antips...

OBJECTIVE To evaluate maternal medical and perinatal outcomes associated with antipsychotic drug use in pregnancy. DESIGN High dimensional propensity score (HDPS) matched cohort study. SETTING Multiple linked population health administrative databases in the entire province of Ontario, Canada. PARTICIPANTS Among women who delivered a singleton infant between 2003 and 2012, and who were el...

OBJECTIVE We report 3 cases of intraoperative floppy-iris syndrome (IFIS) during cataract surgery in patients without a history of selective α1-blocker use but with a long-term history of antipsychotic drug use. We reviewed previously reported cases of antipsychotic drug-associated IFIS cases. DESIGN Observational case series. RESULTS In case 1, bilateral IFIS developed in a 39-year-old man...

Repeated administration of antipsychotic drugs to normal rats has been shown to induce a state of dopamine neuron inactivation known as depolarization block, which correlates with the ability of the drugs to exhibit antipsychotic efficacy and extrapyramidal side effects in schizophrenia patients. Nonetheless, in normal rats depolarization block requires weeks of antipsychotic drug administratio...

EMERGENCY nurse 17 Antipsychotic drugs (or neuroleptics) are a large class of drugs which can be divided into three groups: phenothiazine, miscellaneous and atypical (Box 1). They are used to tranquillise patients without impairing consciousness and without causing paradoxical excitement. They are often referred to as major tranquillisers but this is misleading since these drugs also relieve fl...