the central immunological disturbance in systemic lupus erythematosus (sle) is autoantibody production. some of these antibodies affecting components of the cell nucleus are the major characteristics of sle. the present study was aimed to assess importance of anticardiolipin (acl) antibody and its association with clinical state in sle patients. a cross sectional study was performed on 100 pati...

BACKGROUND Although thrombosis is considered the cardinal feature of the antiphospholipid syndrome, chronic vascular lesions are common, particularly in patients with life-threatening complications. In patients who require transplantation, vascular lesions often recur. The molecular pathways involved in the vasculopathy of the antiphospholipid syndrome are unknown, and adequate therapies are la...

BACKGROUND AND PURPOSE Antiphospholipid syndrome may affect the incidence and pathogenesis of cerebrovascular diseases in patients with systemic lupus erythematosus. We compared the spectrum of MR findings in patients with systemic lupus erythematosus with and without antiphospholipid syndrome. MATERIALS AND METHODS We identified 256 patients with systemic lupus erythematosus (45 with, 211 wi...

Antiphospholipid antibodies are known as a heterogeneous group of autoantibodies associated with the hypercoagulable condition affecting the vascular tree with thrombosis entitled antiphospholipid syndrome (1). Antiphospholipid syndrome is an autoimmune disorder with various etiology that contains cellular, genetic, molecular and pathogenic mechanisms. The antiphospholipid syndrome clinical cha...

Graham Hughes described in 1983 a syndrome, characterized by recurrent arterial and venous thrombosis, pregnancy morbidity, thrombocytopenia, and the presence of antiphospholipid antibodies (aPL), which was named antiphospholipid syndrome [Hughes, 1983]. Many other features of this syndrome were identified during the time. In present, antiphospholipid syndrome is considered a systemic form of a...

APS can be primary or secondary. Primary antiphospholipid syndrome occurs in the absence of any other related disease. Secondary antiphospholipid syndrome is often associated with systemic lupus erythematosus and less frequently with infections, drugs and other diseases. Serologic markers are antiphospholipid antibodies, lupus anticoagulant and anticardiolipin. In rare cases, APS leads to rapid...

Specific neurological syndromes have been reported in the presence of antiphospholipid antibodies.'"2 Chronic active hepatitis as part of the antiphospholipid syndrome has been described in only two patients.34 We report the combination of sinus vein thrombosis together with chronic active hepatitis in a young woman with antiphospholipid syndrome. This patient was 13 months post-partum and stil...

See also Scully M-F. Moderate dose oral anticoagulant therapy in patients with the antiphospholipid syndrome? Yes. This issue, pp 840–1; Rickles FR, Marder VJ. Moderate dose oral anticoagulant therapy in patients with the antiphospholipid syndrome? No. This issue, pp 842–3; Khamashta MA, Hunt BJ. Moderate dose oral anticoagulant therapy in patients with the antiphospholipid syndrome? No. This i...

The Sneddon's syndrome is a rare disorder characterized by the occurrence of cerebrovascular disease associated with livedo reticularis. The antiphospholipid syndrome is the most frequent type of acquired thrombophilia, defined by the occurrence of thrombosis or pregnancy morbidity in the presence of persistently positive antiphospholipid antibodies. Approximately 80% of Sneddon's syndrome pati...