BACKGROUND/AIM Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in hypercholesterolemic subjects treated with atorvastatin. In this study, we aimed to evaluate effects of atorvastatin treatment on functionality of HDL, oxidative stress, and endothelial ...

• Biochemical composition of milling fractions common and tartary buckwheat was evaluated. Significant differences between were observed. Antioxidant properties higher compared to buckwheat. Contents all macroelements most the microelements highest in bran fraction. Buckwheat is a pseudocereal with important nutritional qualities great potential for broad consumption. The study aimed determine ...

The reactivity of tocopherols with 2,2-diphenyl-1-picrylhydrazyl (DPPH) was studied in model systems in order to establish a method for quantifying vitamin E in plant oils. The method was optimized with respect to solvent composition of the assay medium, which has a large influence on the course of reaction of tocopherols with DPPH. The rate of reaction of α-tocopherol with DPPH is higher than ...

The number of chemicals for which environmental regulatory decisions are required far exceeds the current capacity for toxicity testing. High-throughput screening commonly used for drug discovery has the potential to increase this capacity. The adverse outcome pathway (AOP) concept has emerged as a framework for connecting high-throughput toxicity testing (HTT) and other results to potential im...

NASA Langley has developed a multi-mode decision support system for pilots operating in a Distributed AirGround Traffic Management (DAG-TM) environment. An Autonomous Operations Planner (AOP) assists pilots in performing separation assurance functions, including conflict detection, prevention, and resolution. Ongoing AOP design has been based on a comprehensive human factors analysis and evalua...

The aim of the studies was to evaluate the influence of quercetin on etoposide-induced DNA damage in rat bone marrow cells and on changes in the activities of superoxide dismutase (SOD), catalase and antioxidant power in lung tissue (AOP). Quercetin was administrated by gavage at a dose of 135 mg/kg b.w. for three consecutive days, and one hour after the last dose, etoposide was intraperitoneal...

the state-based behavior of AOP program with the consideration of the interactions between the base modules and aspects. Based on the model, test cases can be derived so as to uncover the potential state behavior errors in the AOP programs. In addition, an example is provided to show the effectiveness of the proposed approach.

OBJECTIVE To examine the potential value of preinduction cervical length, cervical elastography and angle of progression (AOP) in prediction of successful vaginal delivery and induction-to-delivery interval. METHODS This was a prospective study in 99 women with singleton pregnancy undergoing preinduction ultrasound assessment at 35-42 weeks' gestation. Cervical length, elastographic score at ...

An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of a biological system and an adverse outcome at a level of biological organization of regulatory relevance. Systematic organization of information into AOP frameworks has potential to improve regula...