The therapeutic potential of snake venoms for pain control has been previously demonstrated. In the present study, the antinociceptive effects of Micrurus lemniscatus venom (MlV) were investigated in experimental models of pain. The antinociceptive activity of MIV was evaluated using the writhing, formalin, and tail flick tests. Mice motor performance was assessed in the rota rod and open field...

In Sri Lankan traditional medicine, the decoction of leaves of the plant Pongamia pinnata (L.) is claimed to possess antinociceptive activity. However, as yet, its antinociceptive potential has not been scientifically investigated. The aim of this study was to investigate the antinociceptive potential of an aqueous leaf extraction (ALE) of P. pinnata in rats, using three algesiometric methods (...

objective: this study was aimed to examine the antinociceptive and anti-inflammatory effects of urtica dioica leaf extract in animal models. materials and methods: hydroalcoholic extract of the plant leaves was prepared by percolation method. male swiss mice (25-35 g) and male wistar rats (180-200 g) were randomly distributed in control, standard drug, and three experimental groups (n=6 in each...

N-Acyloctahydropyrido[3,2,1-ij][1,6]naphthyridines were synthesized as derivatives of matrine-type alkaloids, and the structure-activity relations were examined by the acetic acid-induced abdominal contraction test. The antinociceptive potencies of N-acyloctahydropyrido[3,2,1-ij][1,6]naphthyridines were significantly lower than those of (+)-matrine. The antinociceptive effects of N-benzyloctahy...

OBJECTIVE To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL). METHODS Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw. RESULTS The results indicated that MRCL exhibited considerable antinociceptive activity again...

UNLABELLED Transcranial electrostimulation (TES) has been reported to elicit significant analgesia, allowing a substantial reduction of intraoperative opioids. Acceptance of TES into clinical practice is hampered by lack of controlled clinical trials and inconclusive animal data regarding the TES antinociceptive action. This inconclusive data may be explained, in part, by failure in rat experim...

BACKGROUND & OBJECTIVES Several studies have shown the possible analgesic effects of gabapentin, widely used as an antiepileptic. Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats. METHODS The mice were divided into 10 groups (n=7) with various trea...

Water, methanol and ethanol extracts of Evodia rutaecarpa were tested for antinociceptive activity, which were correlated with the contents of evodiamine, rutaecarpine and evodine. Determination of contents was achieved by chromatographic techniques. Extracts were evaluated for antinociceptive activities using hot-plate test; acetic acid-induced writhing test and formalin test. All three extrac...

Four dihydroxy flavone derivatives viz 5,3′-, 7,3′-, 2′,3′and 2′,4′-dihydroxy flavones were evaluated for their antinociceptive response in doses ranging from 3 to 200 mg/kg (s.c). Antinociception in mice was studied employing acetic acid induced abdominal constrictions, formalin induced nociception and tail immersion assay procedures. Involvement of opioid mechanism in the antinociceptive acti...