We have previously demonstrated that both endomorphin-1 and endomorphin-2 produce their antinociception by the stimulation of mu-opioid receptors. However, the antinociception induced by endomorphin-2 contains an additional component, which is mediated by the release of dynorphin A (1-17) acting on kappa-opioid receptors. These studies were done to determine whether the antinociception induced ...

Reactive oxygen species (ROS) are involved in neuropathic pain, a complicated condition after nerve tissue lesion. Vitamin D appears to improve symptoms of pain and exhibits antioxidant properties. We investigated the effects oral administration vitamin D3, active form D, on nociception, sciatic functional index (SFI), spinal cord pro-oxidant markers rats with chronic constriction injury (CCI) ...

Although intravenous administration of [D-penicillamine2, 5]-enkephalin (DPDPE) produces significant antinociception in rodents, the duration of antinociception is short ( approximately 15 min). The present study was conducted to test the hypothesis that duration of antinociception for DPDPE is determined by both systemic and regional disposition (i.e., blood-brain translocation), and that the ...

BACKGROUND (-)-Pentazocine has been hypothesized to induce analgesia via the κ-opioid (KOP) receptor, although the involvement of other opioid receptor subtypes in the effects of pentazocine remains unknown. In this study, we investigated the role of the μ-opioid (MOP) receptor in thermal, mechanical, and chemical antinociception induced by (-)-pentazocine using MOP receptor knockout (MOP-KO) m...

To determine the role of spinal mu-opioid receptor subtypes in antinociception induced by intrathecal (i.t.) injection of endomorphin-1 and -2, we assessed the effects of beta-funaltrexamine (a selective mu-opioid receptor antagonist) naloxonazine (a selective antagonist at the mu(1)-opioid receptor) and a novel receptor antagonist (3-methoxynaltrexone) using the paw-withdrawal test. Antinocice...

Flavone, dextrose and long swim stress exhibited antinociception. Degree of antinociception was greater with long swim stress as compared to flavone or dextrose. Combination of these treatments resulted in potentiation of antinociception. Naloxone (opioid antagonist; 5 mg/kg i.p.) antagonised flavone or long stress induced antinociception showing opioid medicated mechanism, however, failed to r...

alpha2-Adrenergic receptor (AR)-selective compounds produce antihypertensive and antinociceptive effects. Moxonidine alleviates hypertension in multiple species, including humans. This study demonstrates that intrathecally administered moxonidine produces antinociception in mice. Antinociception was detected via the (52.5 degrees C) tail-flick and Substance P (SP) nociceptive tests. Moxonidine ...

BACKGROUND In the present study, the effect of dextromethorphan on antinociception and tolerance induced by water swim-stress in the formalin test was investigated. METHODS Swim-stress at 8 masculineC induces antinociception in both phases of the formalin test. Intraperitoneal administration of dextromethorphan (60 mg/kg) also induces antinociception in the second phase of the formalin test. ...

in the present study the effects of both cck receptor agonists and antagonists on antinociception induced by morphine in the tail-flick test have been evaluated. m orphine induced dose-dependent antinociception in mice. the response of morphine was potentiated by sulfated cholecystokinin-8 (cck-8s) but not by unsulfated cholecystokinin-8 (cck-8u). the cck receptor antagonists mk-329 and l-365, ...

Background The use of paracetamol or nefopam for postoperative pain control is limited by the need high doses associated with unwanted effects. Previous works suggest positive interactions between both compounds that may be exploited to obtain potentiation antinociception. Methods Mechanical and heat antinociception induced oral paracetamol, their combination was studied isobolographic analysis...