The outbreak of antimicrobial resistance, together with the lack of newly developed antimicrobial drugs, represents an alarming signal for both human and animal healthcare worldwide. Selection of rational dosage regimens for traditional antimicrobial drugs based on pharmacokinetic/pharmacodynamic principles as well as development of novel antimicrobials targeting new bacterial targets or resist...

Antimicrobial drugs often seem bewildering and confusing because of the large number of drugs and diverse types of microorganisms against which they are used. To learn and understand the many aspects of these drugs and be able to administer appropriate chemotherapy, it is important to utilize reading materials that are organized, complete, and up to date. The Antimicrobial Drugs by Pratt and Fe...

Knowledge of the antimicrobial pharmacodynamic characteristics of a drug (inhibition of growth, rate and extent of bactericidal action, and postantibiotic effect) provides a more rational basis for determination of optimal dosing regimens in terms of the dose and the dosing interval. This article reviews concepts of antimicrobial pharmacodynamics, the effect of pharmacodynamics on the emergence...

The aim of the investigation was to throw light on the question whether drugs other than antibiotics and chemotherapeutic agents exert an antimicrobial effect. In order to elucidate this, the antimicrobial effect of selected psychotherapeutic drugs and their stereo-isomeric analogues was studied. The development of psychotherapeutic drugs from aniline dyes has been reviewed against the backgrou...

backgrounds: different susceptibility rates of pathogenic bacteria to antimicrobial agents are considered major factors in the choice of drugs and the success of treatments. concerns have been raised regarding the emergence of antimicrobial resistance among pathogenic bacteria that may result in unpredictable antimicrobial susceptibilities and therapy failure. objectives: the purpose of this in...

Resistance of Streptococcus pneumoniae to antimicrobial drugs is increasing. To investigate the relationship between antimicrobial use and susceptibility of S. pneumoniae isolates at 24 U.S. medical centers, we obtained data on outpatient antimicrobial-drug use for the regions surrounding 23 of these centers. We found an association between decreased penicillin susceptibility and use of beta-la...

Antimicrobial peptides (AMPs) have attracted attention as next-generation antimicrobial drugs. Designing AMPs while considering multiple properties, such activities and toxicity, requires numerous trials errors by chemists. In...