نتایج جستجو برای: antimetastatic

تعداد نتایج: 993  

Journal: :Seminars in thrombosis and hemostasis 2007
Dirk Simonis Katrin Christ Susanne Alban Gerd Bendas

Selectins are adhesion receptors that participate in inflammation and tumor cell metastasis. The anti-inflammatory and antimetastatic activities of heparins have been related partly to their ability to interact with P- and L-selectin. The recent findings that various heparins differ in antimetastatic activity were explained by differences in their P- and L-selectin binding ability. To obtain da...

Journal: :journal of sciences, islamic republic of iran 2012
m.r. noori-daloii

the lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. however in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. the metastasis of lung cancer is highly dependent of expression of matrix me...

Journal: :Advances in Pharmacoepidemiology & Drug Safety 2012

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2016
Heinz Läubli Ajit Varki Lubor Borsig

TO THE EDITOR: The well-performed and important FRAGMATIC (Dalteparin in Preventing Blood Clots in Patients With Lung Cancer) trial reported by Macbeth et al concluded that the addition of prophylactic doses of the lowmolecular weight heparin (LMWH) dalteparin for 24 weeks to standard of care in patients with lung cancer did not improve overall survival; the rate of venous thromboembolism was s...

2014
Thamilvaani Manaharan Ramaraj Thirugnanasampandan Rajarajeswaran Jayakumar Gunasekar Ramya Gogul Ramnath M S Kanthimathi

Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant ((*) P < 0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A ...

2017
Aneta Gandalovičová Daniel Rosel Michael Fernandes Pavel Veselý Petr Heneberg Vladimír Čermák Luboš Petruželka Sunil Kumar Victoria Sanz-Moreno Jan Brábek

In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term 'migrastatics' for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which ar...

2013
Sau Har Lee Indu Bala Jaganath Rishya Manikam Shamala Devi Sekaran

BACKGROUND Lung cancer constitutes one of the malignancies with the greatest incidence and mortality rates with 1.6 million new cases and 1.4 million deaths each year. Prognosis remains poor due to deleterious development of multidrug resistance resulting in less than 15% lung cancer patients reaching five years survival. We have previously shown that Phyllanthus induced apoptosis in conjunctio...

2015
DAMIÁN MACHUCA PAULA CHIARELLA DANIELA MONTAGNA GRACIELA DRAN ROBERTO P. MEISS RAÚL A. RUGGIERO

Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. While former studies have indicated that T-cell dependent processes mediate CR in hosts bearing immunogenic small tumors, the most universal manifestation of CR induced by immunogenic and non-immunogenic large tumors had been associated with an a...

2003
Chun-Nan Lee Cheng-Wen Wu Chao-Wen Cheng Steve R. Roffler Bor-Luen Chiang Chia-Hui Lo Shan-Chih Lee Pin-Yi Wu Wen-Yu Pan Jui Su

2017
Lin Tian Xiang H.F. Zhang Sendurai A. Mani

Despite the successful therapeutic regimens for the treatment of primary tumors, effective interventions for metastatic lesions are lacking. Metastasis is a complex process, wherein the cancer cells pass through multifaceted steps from the primary site to establish tumor at the distant site. This multifaceted process begins with the establishment of highly vascularized primary tumor, local inva...

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