Pancreatic cancer is a deadly and aggressive disease. Less than 1% of diagnosed patients survive 5 years with an average survival time of only 4-8 months. The only option for metastatic pancreatic cancer is chemotherapy where only the antimetabolites gemcitabine and 5-fluorouracil are used clinically. Unfortunately, efforts to improve chemotherapy regimens by combining, 5-fluorouracil or gemcit...

Pettus gave everything he had as a medical missionary in China and Dr. Edward H. Hume has drawn a clear and sympathetic picture of this man, his aspirations, and those qualities which distinguished him as a medical scientist at home and abroad. On 23 November 1945 was received the melancholy cablegram from Huangping, China, which read as follows: "Dr. Pettus killed in airplane accident at Huang...

With the realization in 1940 (1) that structural analogues of a metabolite frequently prevent utilization of that metabolite, it became possible to develop antimetabolites which block specific biosynthetic pathways. By blocking various steps in a biosynthetic pathway, antimetabolites are useful for elucidating intermediary metabolism. It was the object of the present study to investigate the bi...