CONTEXT The emergence and spread of Plasmodium falciparum-resistant parasites to nearly all available antimalarial drugs pose a threat to malaria control and necessitates the need to continue the search for new effective and affordable drugs. Ethnomedicine has been shown to be a potential source of antimalarial compounds or source of template for the synthesis of novel antimalarial molecules. ...

BACKGROUND The development of resistant to current antimalarial drugs is a major challenge in achieving malaria elimination status in many countries. Therefore there is a need for new antimalarial drugs. Medicinal plants have always been the major source for the search of new antimalarial drugs. The aim of this study was to screen selected Malaysian medicinal plants for their antiplasmodial pro...

ETHNOPHARMACOLOGICAL RELEVANCE Malaria continues to kill over a million people each year and in many populations affected by malaria, conventional drugs are often unaffordable or inaccessible. Historically, plants have been a prominent source of antimalarial drugs. Those plants currently used by indigenous people to treat malaria should be documented and investigated as potential sources of new...

In order to collect ethnobotanical information about antimalarial plants which is essential for the further evaluation of the efficacy of plants an antimalarial remedies, we investigated the management of malaria with traditional herbal remedies, including the use, preparation and administration, by traditional healers in Tanzania. Interviews with traditional healers were conducted in different...

malaria is a major international public health problem. drug-resistant parasites have made treatment and control of malaria more difficult. therefore, safe, affordable and effective new drugs are urgently needed. traditional medicine is an important source for new drugs. determining the ancient medicinal books was the first step of this study for finding malaria or disease that has symptoms lik...

Malaria remains one of the leading public health problems in Cameroon as in other parts of Sub-Saharan Africa. In the past decades, this situation has been aggravated by the increasing spread of drug-resistant Plasmodium falciparum strains. New antimalarial drug leads are therefore urgently needed. Traditional healers have long used plants to prevent or cure infections. This article reviews the...

The present study was conducted to investigate the in vitro antimalarial activity of Flacourtia flavescens Willd. (Flacourtiaceae) and Rytigynia canthioides (Benth.) Robyns (Rubiaceae). These two plants are used in Benin folk medicine to treat malaria and fever. Antimalarial activity was assayed on fresh clinical isolates of chloroquine resistant Plasmodium falciparum using the in vitro semi-mi...

Abstract Development of resistance by malaria parasites to conventional antimalarial drugs has rejuvenated the exploration herbal medicine as alternatives. Also, increasing rate use remedies in combination with (both synthetic and semi-synthetic) inspired researchers validate their herb-drug interaction effects. This review evaluated outcomes between drugs. With aid electronic databases, Pubmed...

Developing countries, where malaria is endemic, depend strongly on traditional medicine as a source for inexpensive treatment of this disease. However, scientific data to validate the antimalarial properties of these herbal remedies are scarce. Consequently, it is important that antimalarial medicinal plants are investigated, in order to establish their efficacy and to determine their potential...

Ten extracts with different polarity from two Iranian Artemisia species, A. armeniaca Lam. and A. aucheri Boiss, were screened for their antimalarial properties by in vitro   β -hematin formation assay. Dichloromethane (DCM) extracts of both plants showed significant antimalarial activities with IC50 values of 1.36±0.01 and 1.83±0.03 mg/mL and IC90 values of 2.12±0.04 and 2.62±0.09 mg/mL for A....