THE ANTILEISHMANIAL ACTIVITY OF THREE ORGANIC SOLVENT EXTRACTS AND WATER RESIDUE OF THE PLANTS: Acacia nilotica (Mimosaceae) (husk), Ambrosia miratima (Astraceae) (aerial shoot) and Azadarichta indica (Meliaceae) (leaves) were tested in vitro against Leishmania donovani promastigotes. The study revealed that the extracts of A. nilotica and A. miratima have effectious antileishmanial activity at...

Benzimidazole is a bicyclic heterocyclic aromatic compound in which benzene fused to imidazole moiety. holds vital role the field of medicinal chemistry possesses wide variety pharmacological activities like antibacterial, anti cancer, antifungal, antileishmanial, tubercular, viral and malarial respectively, hence benzimidazole moiety attracting chemist synthesize different derivatives with act...

objective: homalium letestui pellegr (flacourtiaceae) is used in traditional medicine in parts of nigeria for the treatment of malaria, ulcer, and inflammatory diseases and as an aphrodisiac. this investigation was aimed to evaluate the cytotoxic, immunomodulatory, and antileishmanial properties of stem extract and fractions of homalium letestui (h. letestui). materials and methods: cytotoxic a...

Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antilei...

A great number of sesquiterpenes are reported in the available literature as good antileishmanial leads. However, their mode of action at the molecular level has not been elucidated. The lack of molecular studies could be considered an impediment for studies seeking to improve sesquiterpene-based drug design. The present in silico study allows us to make important observations about the molecul...

Background: Leishmaniasis is an infectious disease caused by various species of the Leishmania parasites. An effective vaccine or drug to prevent the infestation or a suitable medication to cure the disease without side effects has not been provided yet.  Objectives: The use of medicinal herbs in the treatment of many diseases, especially parasitic ones, dates back to prehistoric times. This a...

BACKGROUND Leishmaniasis is a neglected tropical parasitic diseases affecting millions of people around the globe. Quinazolines are a group of compounds with diverse pharmacological activities. Owing to their promising antileishmanial activities, some 3-aryl-2-(substitutedstyryl)-4(3H)-quinazolinones were synthesized in good yields (65.2% to 86.4%). RESULTS The target compounds were synthesiz...