نتایج جستجو برای: antiher2
تعداد نتایج: 27 فیلتر نتایج به سال:
Características clínicas y demográficas en pacientes con cáncer de mama jóvenes de 40 años o menores
Objetivos: según la información de incidencias y mortalidad Globocan del periodo 2018, el cáncer mama es nuevo segundo más frecuente en mundo mujeres con un estimado 2.088.849 (11.6 %) casos diagnosticados quinta causa muerte por (626 679 (6.6 %)). En Colombia primero incidencia 13.380 (14.01 nuevos se presentaron 3.702 (8.79 muertes; corresponde a tercera cáncer. General: describir frecuencia ...
Metastatic breast cancer is a heterogeneous disease that presents in varying forms, and a growing number of therapeutic options makes it difficult to determine the best choice in each particular situation. When selecting a systemic treatment, it is important to consider the medication administered in the previous stages, such as acquired resistance, type of progression, time to relapse, tumor a...
T cell checkpoint blockade and T cell costimulation, two types of immunotherapy undergoing active clinical investigation, have led to improved outcomes for patients with different types of advanced cancer. Given that these approaches can result in durable remissions, there is interest in increasing the number of patients who can benefit from them. Interestingly, there is evidence that patients ...
Commercializing scientific research or a breakthrough idea is really no different, in principle, from commercializing anything, except perhaps that it’s more difficult in practice because of the steps required to turn basic research into something practical and because you are looking for a market for a product, rather than designing a product to fit an established, or obvious market. Commercia...
BACKGROUND Quantum dots are fluorescent nanoparticles with unique photophysical properties that allow them to be used as diagnostic, therapeutic, and theranostic agents, particularly in medical and surgical oncology. Near-infrared-emitting quantum dots can be visualized in deep tissues because the biological window is transparent to these wavelengths. Their small sizes and free surface reactive...
The goal of this study was to characterize a series of antiHer2/neu immunotoxin constructs to identify how different antibodies and linker choices affect the specificity and cytotoxicity of these proteins. We constructed a series of immunotoxins containing either the human single-chain antibody (scFv) C6.5 or the murine scFv e23 fused to the highly toxic recombinant gelonin (rGel) molecule. Bas...
CD1d-restricted invariant NKT cells (iNKT) exert potent anti-tumor effects by virtue of their ability to transactivate NK cells, dendritic cells and T lymphocytes. However, their use in cancer immunotherapy has been limited by their short-lived activation followed by a phase of long-term anergy after a single injection of the high affinity CD1d ligand alpha-galactosylceramide (aGC). Instead, we...
Purpose The goal of this study was to characterize the distribution of HER2 receptor targeted immunoliposomes in a mouse model of human breast cancer and compare this to non-targeted sterically stabilized liposomes. Introduction Liposomes are currently being investigated as a means of improving delivery of chemotherapeutic agents to tumors. Sterically stabilized liposomes have been studied beca...
therapies approved; capecitabine plus lapatinib is an option [4, 5]. With regard to trastuzumab, its activity in the CNS has always been considered very poor, because of difficulty of penetration and insufficient activation of antibody-dependent cellular cytotoxicity (ADCC) in the brain. We report the case of a 63-year-old woman with HER2-positive brain metastases who experienced long-term remi...
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