The microbial transformation of oral contraceptive norethisterone (1) by Cephalosporium aphidicola afforded an oxidized metabolite, 17α-ethynylestradiol (2), while the microbial transformation of 2 by Cunninghamella elegans yielded several metabolites, 19-nor-17α-pregna-1,3,5 (10)trien-20-yne-3,4,17β -triol (3), 19-nor-17α-pregna-1,3,5 (10)-trien-20-yne-3,7α ,17β -triol (4), 19nor-17α-pregna-1,...

Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of genera Boenminghausenia, Clausena Ruta. The distribution these compounds appears to be restricted plants family Rutaceae. To date, there have been a consider...

To evaluate antifertility mode of action of extracts of Juniperus communis Linn., its various extracts were investigated for estrogenic, antiestrogenic, progestagenic and antiprogestagenic properties in laboratory animals. Investigations reveal that the extract possessed only antiprogestational activity which accounts for its antifertility effect.

Results of past animal studies have indicated the antifertility effects of phthalate esters and additional studies have suggested the potential mutagenic effects at very high doses. A toxicity study in mice has also been conducted in which chronic LD50 values were calculated for a group of phthalate esters. For DEHP, for example, the acute LD50 was 38.35 ml/kg, but after 10 weeks the value fell...

New synthetic drugs have much more drawbacks, it shows side effect on health. This problem can be minimized by herbal formulation and Butea monosperma tree has been accepted traditionally in the form of natural medicine .The present paper mainly focus on Reviews of Butea Monosperma formerly known Butea Frondosa which has been traditionally reported as to possess antibacterial, antimicrobial,ant...

Ancient literature mentions the use of a number of plants/preparations for fertility regulation. Some local contraceptive agents have also been described in Ayurvedic and Unani texts. Documented experiments or clinical data are, however, lacking. Therefore, the present study was undertaken to explore the antifertility and estrogenic activity of ethanolic extract of the roots of Hibiscus rosa-si...

Fertility is possibly the most important capability contained within living cells or species. Therefore, finding the most efficacious way to enhance or promote fertility is the main goal of all living things. To best manage nature's strong predisposition for fertility, plant-based traditional medicines for birth control have long been incorporated into medical practices throughout the world, in...