gabapentin (gpn) is a new antiepileptic agent currently in used as add-on therapy in adult patients suffering from partial seizures. the extent of liver damage at different dosage and long term treatment with gpn is not yet clear. therefore this study was undertaken to find out the possibility of liver damage by this drug. adult male (wistar) rats of 180-220 g were administered intraperitoneall...

Many patients with epilepsy suffer also from coexisting psychological problems. These mental co-morbidities have a significant impact on quality of life of patients with epilepsy. Recent studies have shown that although antiepileptic drugs (AEDs) treat epilepsy, they may increase risk of mental disorders in these patients . Due to the lack of adequate research in this area, we assess...

background: the physiologic function of carnitine, oxidation of fatty acid and lipid  metabolism, is severely affected in carnitine deficiency, secondary forms of which lead to renal tubular disorders and chronic renal failure. reduction in serum carnitine has been frequently reported in patients and experimental animals treated with antiepileptic drugs, one of which, valproic acid has consiste...

OBJECTIVE To describe access to antiepileptic drug therapy and estimate the prevalence of epilepsy in children in Camagüey Province, Cuba. METHODS All the community pharmacies in the province were visited and information collected about the number of children receiving antiepileptic drugs in 2009. Availability and cost of each antiepileptic drug were determined. The prevalence of epilepsy was...

many patients with epilepsy suffer also from coexisting psychological problems. these mental co-morbidities have a significant impact on quality of life of patients with epilepsy. recent studies have shown that although antiepileptic drugs (aeds) treat epilepsy, they may increase risk of mental disorders in these patients . due to the lack of adequate research in this area, we assessed psychiat...

OBJECTIVE To investigate the potential impact of exposure to anti epileptic medications during the first-trimester of pregnancy on major malformations. STUDY DESIGN A retrospective cohort study comparing all pregnancies of women with and without exposure to antiepileptic medications during pregnancy was performed. A computerized database of medications dispensed from 1998 to 2008 to all women...

Epilepsy is common in patients with brain tumours and can substantially affect daily life, even if the tumour is under control. Several factors affect the mechanism of seizures in brain tumours, including tumour type, tumour location, and peritumoral and genetic changes. Prophylactic use of antiepileptic drugs is not recommended, and potential interactions between antiepileptic and chemotherape...

Epilepsy is one of the most important diseases of nervous system that involves 0.5-1% of the population. In spite of new developments in antiepileptic drugs, between 20-30% of epileptic patients can not be controlled and even those who are controlled with antiepileptic drugs suffer from their adverse events. Epileptic patients have different challenges in relation to the disease and its medicat...

PURPOSE The ketogenic diet (KD) has been used as an effective antiepileptic treatment for nearly a century. Inhibition of glycolysis and increased levels of ketone bodies are both known to contribute to the antiepileptic effects of the KD. Neuron-restrictive silencer factor (NRSF), also known as RE-1 silencing transcription factor (REST), is implicated in the antiepileptic effects of the glycol...