The value of tablets and paper discs as reservoirs of antimicrobial agents for use in sensitivity testing was compared. Antibiotics that were unstable in paper discs showed no demonstrable loss of activity in tablets over a period of 50 days under adverse storage conditions. The antibiotic content of commercially prepared tablets is very high in comparison with the accepted content of paper dis...

A rapid method of evaluating the susceptibility of spirochaetes to antibiotics would be convenient for investigators. Schneierson (1954) described a method of testing the susceptibility of strains of potentially pathogenic species, in which discs containing standard amounts of antibiotics were dropped into broth, and the broth was inoculated with the organism under study. He found that the resu...

The resistance of Staphylococcus aureus to methicillin and related drugs can be reliably determined by using the Kirby-Bauer method of susceptibility testing if the incubation temperature is 35 C or below, but resistance may be missed at 37 C. The 1-mug discs of oxacillin and nafcillin or the 5-mug discs of methicillin may be used for this purpose but not the 1-mug discs of cloxacillin. The lat...

Good quality of antibiotic discs is a fundamental prerequisite to accurate antibiotic susceptibility tests. Capillary electrophoresis (CE) is a widely used method for quantitative analysis. Here, using ceftazidime as an example, we report an easy-to-perform strategy to determine ceftazidime content in discs. First, a serial of ceftazidime standard solutions was prepared to determine the detecti...

Antibiotic resistance is a growing threat. Fifty non repetitive multi drug resistant gram negative bacterial isolates were screened for ESBL, AmpC, ESBL-AmpC co-production using antibiotic tablets. Of these 56% were Escherichia coli, 16% were Klebsiella spp., 39.6% produced ESBLs, 17.2% AmpC and 13.8% showed co-production. Antibiotic tablets sensitivity for ESBL detection was 93.9% compared to ...

BACKGROUND AND PURPOSE Many investigations on biodegradable materials acting as an antibiotic carrier for local drug delivery are based on poly(lactide). However, the use of poly(lactide) implants in bone has been disputed because of poor bone regeneration at the site of implantation. Poly(trimethylene carbonate) (PTMC) is an enzymatically degradable polymer that does not produce acidic degrada...