conclusions: this study detected multiple drug resistance in pseudomonas aeruginosa including resistance to β-lactams, aminoglycosides, and fluoroquinolones. therefore, identification of drug resistance patterns in p. aeruginosa and detection of pan-resistant producing isolates are of great importance in prevention and control of infections in burn center ward. background: serious infections by...

Introduction: Bacterial antibiotic resistance has become one of the biggest threats to global health. In the United States alone, at least 2 million cases of illness and 23,000 of deaths are caused by antibioticresistant bacteria annually. The overuse of antibiotics is the most important factor responsible to the development of antibiotic resistance around the world [1]. To overcome bacterial d...

background: enterococci faecalis are predominating species of enterococci causing nosocomial infections. acquisition of resistance to antibacterial agents, and ability to transfer the resistant genes made them clinically important. this study was performed to determine the frequency of isolation of different species of enterococci , and the antibacterial resistance pattern of the isolated speci...

the resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. infection of drug-resistance bacteria seriously threatens human health. currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. in this paper, a series of (s,z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

We examined whether household use of antibacterial cleaning and hygiene products is an emerging risk factor for carriage of antimicrobial drug-resistant bacteria on hands of household members. Households (N = 224) were randomized to use of antibacterial or nonantibacterial cleaning and hygiene products for 1 year. Logistic regression was used to assess the influence of antibacterial product use...

Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA topoisomerases, DNA gyrase and topoisomerase IV, are validated antibacterial drug targets with multiple prospective drug binding sites, including th...

background: despite the discovery of numerous antibiotics, drug resistance still remains as a major problem. therefore, it is important to introduce and replace new sources of drug such as medicinal plants with antimicrobial properties. objective: the genus clematis (ranunculaceae family) has six species in iran. aerial parts of clematis have been used to cure fever and chronic diseases such as...

neonatal bacterial sepsis is one of the major cause of morbidity and mortality in neonates. this retrospective study was performed to determine the incidence of bacterial sepsis with focus on gram negative organisms in neonates admitted at beheshti hospital in kashan, during a 3-yr period, from september 2002 to september 2005. blood culture was performed on all neonates with risk factors or si...