Background & Aim:Albizia chevalieri Harms (Mimosaceae) is widely used in traditional medicine to treat various kinds of diseases such as epilepsy, diabetes mellitus, hemorrhoids, asthma, leprosy and gonorrhoea. The effectiveness of its leaf extract in the management of epilepsy is widely acclaimed among communities in northern Nigeria. This study aimed at evaluating th...

Objective The anti-epileptogenic drug levetiracetam has anticonvulsant and anti-epileptogenesis effects. Synergy between cell death and inflammation can lead to increased levels of apoptosis inhibitory factors and brain-derived neurotrophic factor, aberrant neurogenesis and extended axon sprouting. Once hyperexcitation of the neural network occurs, spontaneous seizures or epileptogenesis develo...

Epileptogenic localization is a critical factor for successful epilepsy surgery. Determining the epileptogenic hippocampus with single channel intracranial electroencephalography (iEEG) recording is beneficial to decrease the risk of infection compared with that based on multi-channel iEEGs. Delay permutation entropy (DPE) methodology is presented in this study to measure iEEG with different de...

A wide range of substances, including drugs and illicit compounds, increase the risk of epileptic seizures. In this systematic review, the authors address the issue of the epileptogenic potential of marketed drugs, with the aims of providing criteria for the assessment of the cause-effect relationship between drug exposure and the risk of seizures; and to identify the compounds better fulfillin...

An enhanced production of IL-1beta in glia is a typical feature of epileptogenic tissue in experimental models and in human drug-refractory epilepsy. We show here that the selective inhibition of Interleukin Converting Enzyme (ICE), which cleaves the biologically active form of IL-1beta using VX-765, blocks kindling development in rats by preventing IL-1beta increase in forebrain astrocytes, wi...

We would like to present a rare case report describing a case in which new-onset tonic-clonic seizures occurred following an unintentional durotomy during lumbar discectomy and decompression. Unintentional durotomy is a frequent complication of spinal surgical procedures, with a rate as high as 17%. To our knowledge a case of new onset epilepsy has never been reported in the literature. Althoug...

Six cases of convulsive seizures occurring during treatment with viloxazine notified to the Committee on Safety of Medicines (CSM) and two other cases from Japan were reviewed. A critical study of the patient's histories suggests a possible causal connection between drug and seizures in only two of these cases. The occurrence of convulsions is not in keeping with the results of animal experimen...

a. Delineation of structural and functional abnormalities in the putative epileptogenic region b. Prediction of the nature of structural pathology in the putative epileptogenic region’ c. Detection of abnormalities distant from the putative epileptogenic region d. Emerging goals include identification of brain regions important for normal function including primary sensorimotor function, langua...

Microarray profiling was used to investigate gene expression in the hypoxic seizure model of acquired epilepsy in the rat, with the aim of characterizing functional pathways which are persistently activated or repressed during epileptogenesis. Hippocampal and cortical tissues were transcriptionally profiled over a one week period following an initial series of seizures induced by mild hypoxia a...