BACKGROUND Early discontinuation of anti-depressant treatment is common. This study analysed whether socio-economic factors influence early discontinuation among new anti-depressant users aged 20-34 years. METHODS Our study population included all Swedes aged 20-34 years who purchased anti-depressants in 2006 and had not purchased such drugs in the preceding 6 months (n = 25,003). We obtained...

Bekh-e-Karafs has been reported to be effective in a number of ailments in Unani system of medicine. The aqueous extract of the drug was screened for C.N.S. depressant, anti-convulsant and analgesic activities. The central depressant and analgesic activities of the drug were found to be significant while anti-convulsant activity was found to be insignificant. The results are reported here.

BACKGROUND Collaborative care is a complex intervention based on chronic disease management models and is effective in the management of depression. However, there is still uncertainty about which components of collaborative care are effective. We used meta-regression to identify factors in collaborative care associated with improvement in patient outcomes (depressive symptoms) and the process ...

Recent findings support the hypothesis that CB receptor blockade might be associated with antidepressant and anti-stress effects. In the current study, the anti-depressant-like effects of rimonabant were studied in validated models of depression. Rimonabant (4-8mg/kg, i.p.) significantly decreased the duration of immobility in a dose dependent manner in mice forced swim test (FST) and in tail s...

we have studied the effect of amitriptyline, a tricyclic anti-depressant drug on several immune parameters of the balb/c mice in order to evaluate its immunomodulatory effects. results showed that amitriptyline will potentiates all of the immunocytes functions except for the production of pge2 by lps stimulated monocytes. we have also showed that amitriptyline can normalize the immunosuppressiv...

The use of anti-depressant medication has been linked to cardiovascular disease (CVD). We examined the association between anti-depressant medication use and a marker of low grade systemic inflammation as a potential pathway linking anti-depressant use and CVD in two population based studies. Data were collected in a representative sample of 8131 community dwelling adults (aged 47.4±15.9 years,...

Treatment with anti-depressant drugs of 61 inpatients admitted on account of stroke was studied. Eighteen patients (30%) were being so treated. Only 5 patients (17%) with dysphasia were being treated with anti-depressant drugs compared with 13 patients (41%) without dysphasia (P less than 0.05). Dosage levels used were generally low and only one patient had been referred for a psychiatric opini...