objective: the anti-cancer properties of curcumin, a poliphenol extract from the rhizome of curry, has been confirmed by many investigators. however, low levels of uptake, tissue distribution and rapid metabolism has limited its application as an anti-cancer drug. this study is aimed at increasing curcumin's water solubility due to a biodegradable, neutral and non-toxic micellar nano-carrier ca...

spirulina is free-floating filamentous microalgae growing in alkaline water bodies. as early as over 400 years ago, spirulina was eaten as food by the mayas, toltec’s and kanembu in mexico during the aztec civilization. spirulina is a well-known source of valuable food supplements, such as proteins, vitamins, amino acids, minerals, fatty acids, etc. it is widely used in human and animal nutriti...

nigella sativa has attracted healers in ancient civilizations and researchers in recent times. traditionally, it has been used in different forms to treat many diseases including asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, eczema, fever, dizziness and influenza. experimentally, it has been demonstrated that n. sativa extracts and the main constituent of their vola...

stem cell based treatments are being increasingly explored for their possible potential to treat various cancers. mesenchymal stem cells believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. this tumor tropism property of mscs could be utilized to del...

recent studies have indicated the profound  anti-tumor activity of artemisinin's compounds,  among  which;  arteether  is an  oil-soluble derivative of  artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. an experiment was carried out on tumor-bearing balb/c mice to estimate the effects of arteether  on  tumor  growth  and  antitumor  im...

Abstract: Introduction: Cancer, a fatal disease, is the second leading cause of death reason exceeded only by cardiovascular disease. Breast cancer is common well known cancers in woman and is the second leading cause of death after lung cancer. In recent years researchers have focused on diet based on herbal medicine for the prevention and treatment of certain types of cancer. Methods: In th...

We previously reported the role of histone deacetylase 3 (HDAC3) in response to anti-cancer drugs. The decreased expression of HDAC3 in anti-cancer drug-resistant cancer cell line is responsible for the resistance to anti-cancer drugs. In this study, we investigated molecular mechanisms associated with regulation of HDAC3 expression. MG132, an inhibitor of proteasomal degradation, induced the e...

to improve drug selectivity toward target cells, one interesting approach for drug delivery is to use polymer nanoparticles. a two-layered oniom becke3- lyp: uff calculation was carried out to study the structural and thermodynamic properties of the interaction between acetamide derivatives and the pca-peg-pca copolymers. the interaction enthalpies and the gibbs free energies between acetamide ...

A synthetic route to an anti-cancer drug, lapatinib, was devised support the development of a sustainable manufacturing process in South Africa.