background: chemotherapy-induced amenorrhea is one of long term side effects of adjuvant chemotherapy in patients with breast cancer which may interfere with their future reproductive function. although amenorrhea is well recognized, the actual incidence following taxanes remains uncertain. methods: in a cross sectional study, we identified breast cancer patients aged 45 years or younger who we...

BACKGROUND Evidence suggests that interpatient variability in anthracycline metabolic rate may contribute to the cardiotoxicity associated with anthracycline-based chemotherapy. Therefore, polymorphisms in the anthracycline metabolizing enzymes have been proposed as potential biomarkers of anthracycline-induced cardiotoxicity (AIC). METHODS We have previously shown that 13 of the naturally oc...

Anthracyclines are highly effective chemotherapeutic agents used to treat a wide variety of malignancies. Cardiotoxicity is a well recognized side effect of anthracycline therapy that limits the total amount of drug administered and can cause heart failure in some patients. Most experimental data support oxidative stress as the etiology of anthracycline-induced cardiotoxicity. This review will ...

Background: Cancer patients who receive anthracycline-based chemotherapy regimens often discontinue due to cardiotoxicity. Preventing and reducing anthracycline-induced cardiotoxicity (ACT) is a hot topic in cardio-oncology research. Network pharmacology new discipline that integrates pharmacology, bioinformatics, systems biology. It can be used analyze the mechanism of action drugs body from h...

Nogalamycin is an anthracycline antibiotic produced by Streptomyces nogalater. Its aglycone has a unique stereochemistry (7S, 9S, 10R) compared to that of most other anthracyclines (7S, 9R, 10R). The gene snoaL, encoding a nogalonic acid methyl ester cyclase for nogalamycin, was used to generate nogalamycinone, demonstrating that the single cyclase dictates the C-9 stereochemistry of anthracycl...

Conformational analysis of 2,6-dideoxy-2-halo-alpha-L-hexopyranoses (compounds 1-11) has been performed by molecular mechanics and molecular orbital calculations including solvation effects. The numerical results obtained and those obtained from the electrostatic potential calculation have been used together to interpret theoretically the influence of the introduction of the halogen atom at the...

BACKGROUND HER2-positive breast cancer sensitivity to anthracyclines is enhanced when topoisomerase IIα (TOP2A) is co-amplified under both adjuvant and metastatic settings. However, the relationship between anthracycline sensitivity and TOP2A amplification in HER2-positive breast cancers in neoadjuvant settings is not known. METHODS The TOP2A gene status was examined by FISH in biopsies from ...

OBJECTIVE A pilot study to assess the efficacy of ICRF187 as a protective agent against the cardiotoxic effects of anthracycline drugs used to treat childhood malignancies. DESIGN A study of cardiac function in children treated receiving ICRF187 ((s)-(+)-1,2 bis (3,5-dioxopiperazenyl) propane) in addition to anthracycline therapy compared with contemporary controls selected retrospectively on...

The effect of anticancer therapy on cardiovascular regulation was studied in long-term survivors of childhood cancer. Age related changes in systolic (SBP) and diastolic (DBP) blood pressure, mean cardiac interval (CI) and baroreflex sensitivity, expressed in ms/mmHg (BRS) and in Hz/mmHg (BRSf), were monitored after anthracycline treatment. The values found in 20 children treated by anthracycli...

Anthracyclines are among the most active agents for the treatment of breast cancer; their use in combination regimens improves both disease-free and overall survival in patients with breast cancer. Unfortunately, the clinical utility of anthracycline use is limited by a cumulative dose-dependent cardiac toxicity resulting in congestive heart failure. As methods for detecting and treating breast...