We tested the hypothesis that maternal worm infections in pregnancy affect infant motor and neurocognitive development, and that anthelminthic treatment during pregnancy can reverse these effects. We used measures which examine infant motor, cognitive and executive function, including inhibition. We assessed 983 Ugandan infants aged 15 months, using locally appropriate measures within the Enteb...

Helminths infections are also among the most common infections in human, affecting a large proportion of the world’s population in developing countries and produce a global burden of disease. Pherithema posthuma a helminthes is commonly known as earth-worms, Leucas aspera herb is distributed throughout India. the anthelminthic property of Leucas aspera was evaluated using Pherithema posthuma as...

The title compound, C(21)H(24)N(2)O(2), is a phenyl hydrazine derivative of the well known anthelminthic agent α-santonin, which is composed of three fused rings (benzodieneone, cyclo-hexane and γ-lactone). The cyclo-hexa-dienone ring adopts a boat conformation, the cyclo-hexane ring is in a chair conformation and the trans-fused γ-lactone ring adopts a C-envelope conformation. In the crystal, ...

BACKGROUND Information about improvements in the health status of population at-risk of helminth infection after anthelminthic treatment helps to evaluate the effectiveness of the large scale deworming program. The objectives of this study were to assess the impact of anthelminthic treatment on the prevalence and intensity of intestinal helminth infection, haemoglobin level and prevalence of an...

Costus species is a significant restorative and decorative plant used to fix various illnesses. In India 6,000 plants are for traditional herbal medicine. The spicatus commonly known as ‘Spiral ginger’ ‘insulin plant’, wonder drug down blood sugar level hypoglycemic properties. has been found have numerous pharmacological exercises, example, antibacterial, antifungal, anticholineesterase, cance...

This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues of food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee ...

Abstract Background and Aims Early-onset cystic kidney disease is a clinically genetically heterogeneous overlapping group of rare often severe disorders with limited, mostly symptomatic treatment options. We developed utilized inherited polycystic (PKD) models to search for pharmacological agents that can rescue or mitigate the phenotype. Method A high-content screening platform identification...

WHO During the past decade there have been major efforts to plan, implement, and sustain measures for reducing the burden of human disease that accompanies helminth infections. Further impetus was provided at the Fifty-fourth World Health Assembly, when WHO Member States were urged to ensure access to essential anthelminthic drugs in health services located where the parasites – schistosomes, r...

Albendazole is a clinically important anthelminthic agent known to have variable and low oral bioavailability. The aim of this work was to determine whether albendazole, a CYP3A4 substrate, is also a substrate for the multidrug efflux transporter P-glycoprotein. Both in vitro and in vivo methods were used to assess the role of P-glycoprotein-mediated albendazole transport. In cultured LLCPK1, L...