Quantum chemical (MNDo)caleulations have beenused toelucidate the molecular properties and structure - activity relationships of dihydropyridine (DHP) type calcium antagonists. There is a good corielation between the net atomic charges on various atoms of the 4 - phenyl ring of dihydropyridines and pharmacological activity. .Also, activity decreases with increasing free rotation of the phen...

although current guidelines place single leukotriene receptor antagonists use as a therapeutic option in mild persistent asthma, there is still uncertainty about its place. in this study efficiency of montelukast monotherapy in children with moderate persistent asthma was evaluated. children (age 6 to 16) with persistent moderate asthma were treated prospectively with budesonide combined with m...

abstract oculocardiac reflex (ocr) sometimes occurs as a result of pressure on the eye or traction of the intraorbital surrounding structures during ophthalmic surgery. this can result in bradycardiac arrhythmia and cardiac arrest. a 45-year-old female was undergoing an elective squint correction surgery of one eye under local anaesthesia in a private hospital in december 2013. the patient was ...

a case of acute extrapyramidal manifestations consisting of dystonia and akathisia following abrupt discontinuation of propranolol is reported. she responded well to oral propranolol and intramuscular diazepam. extrapyramidal symptoms have commonly been associated with acute or chronic administration of neuroleptic drugs. there have been reports of a substantial number of cases with similar cli...

background: gp41 of hiv (human immunodeficiency virus) is a protein that mediates fusion between viral and cellular membranes. the agent, t-20, which has been approved for hiv inhibition, can restrain gp41 function in the fusion process; nevertheless, it has disadvantages like instability, high cost of production and injection form to be delivered twice a day. methods: several molecules like nb...

fire blight is an important worldwide disease of pome fruits that control of which through antibiotics is particularly critical. in this case and in absence of another chemical methods, the biocontrol methods can be considered as the best alternative for control of fire blight. in this study efficacy of 5 isolates of antagonistic bacteria belongs to pseudomonas fluorescens and pantoea agglomera...

Objective(s): For determining the mechanism of anti-asthmatic effect of thymoquinone, this investigation evaluated the effect of thymoquinone in the presence of selective A2A and A2B adenosine receptor antagonists (ZM241385 and MRS1706, respectively). Materials and Methods: Seventy guinea pigs were randomly divided to 7 groups; control (C), sensitized with ovalbumin (S), sensitized groups pretr...

in this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by bac10fen has been examined in the formalin test. the gaba-b agonist bac10fen induced antinociception in both phases of the formalin test in mice. the dopamine receptor agonists skf 38393 and quinpirole also induced antinociception in both phases of the test. skf 38393 but not quinpirole pote...