Abstract Schistosomiasis, a neglected tropical disease, affects millions of lives and accounts for thousands deaths each year. The Schistosoma parasites depend on two hosts during their lifecycle: snails as intermediate human beings definitive hosts. Therefore, to control ultimately eliminate schistosomiasis relies the reduction snail populations well prevention treatment infections. Praziquant...

Schistosomes are multicellular parasites of humans exhibiting interesting biological adaptations to their parasitic lifestyle. Concerted and in depth analyses of these adaptations and their cell and molecular biology requires further development of molecular genetic tools in schistosomes. In the current study, we demonstrate that a Gaussia luciferase reporter leads to significantly higher level...

In addition to causing one of the great neglected diseases of the world, schistosomes have unusual biological features that further command attention, including their habit of living in the blood of their hosts and the presence of separate, dimorphic sexes. Phylogenetic studies including a more complete sampling of pivotal and rare schistosomes and their relatives, provide an improved framework...

The importance of the IgE response in protection against infection by schistosomes has been demonstrated in both animal models and in man [1,2]. Among the targets of this response [3], the potential role of a protein of 22 kDa has been emphasized [4] and molecules of 20-22 kDa are widely recognized by IgE in human infection sera (manuscript in preparation). We therefore developed a cloning stra...

A better understanding of the molecular mechanisms required for schistosomes to take up glucose, the major nutritional source exploited by these blood flukes from their mammalian hosts and the subsequent metabolism required to fuel growth and fecundity, can provide new avenues for developing novel interventions for the control of schistosomiasis. This aspect of parasitism is particularly import...

cercarial dermatitis or swimmers’ itch is an itchy inflammatory response to the penetration of the skin by non-human schistosome parasites. in the hot season, may to september, in khuzestan province in the south west of iran, swimming in canals and agriculture activities in swampy areas are common. this survey was made on people from villages north of ahwaz city in south west iran, to estimate ...

Schistosomiasis is an important tropical disease affecting approximately 200 million people worldwide. Because of its chronicity and robust immunomodulatory activity, the effects of schistosomes on other diseases, such as allergies, autoimmunity, and infectious diseases, have been studied extensively in both epidemiological and experimental settings. In this paper, we summarize the beneficial a...