epilepsy is one of the most common neuroinflammatory disorders that affect more than 50 million people worldwide. excessive electrical discharges in neurons following neural cell damage or loss leads to recurrent seizures, which are described as epilepsy. one of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (tle), which results from hippocampal sclerosis. cu...

introduction : shared neuropathology hypothesis in schizophrenia and temporal lobe epilepsy has been introduced long term ago. similar neuropathology leads to the analogous clinical features like neuropsychological features as an example. the aim of this study was to examine this hypothesis by the means of comparing neuropsychological functions in these two patient groups. method : present stud...

Epilepsy is one of the most common neuroinflammatory disorders that affect more than 50 million people worldwide. Excessive electrical discharges in neurons following neural cell damage or loss leads to recurrent seizures, which are described as epilepsy. One of the most common and difficult to treat types of epilepsy is Temporal Lobe Epilepsy (TLE), which results from hippocampal sclerosis. Cu...

in this research, we have computationally investigated a mechanism for antiepileptic drugs (aed) and proposed bumetanide as a possible temporal lobe epilepsy (tle) treatment. experimentally it is difficult and devastating to determine the ionic mechanisms of depolarizing currents. it is obvious that chlorine and potassium transients are challenging to isolate pharmacologically and much γ-aminob...

background: we evaluated the diagnostic value of electroencephalography (eeg), video-eeg monitoring (vem) and magnetic resonance imaging (mri) of the brain with epilepsy protocol in patients with complex partial epilepsy. methods: forty-two consecutive patients underwent complete neurological examination, eeg, and mri with a modified epilepsy protocol. a subset of these patients (n = 29) also u...

background: mesial temporal lobe epilepsy (tle) is a remediable epileptic syndrome. about 40% of patients continue to have seizures after standard temporal lobectomy. it has been suggested that some of these patients could actually suffer from a more complex epileptogenic network. because a few papers have been dedicated to this topic, we decided to write an article updating this theme. methods...

Mitochondrial dysfunction has been identified as a potential cause of epileptic seizures and therapy-resistant forms of severe epilepsy. Thus, a broad variety of mutation in mitochondrial DNA or nuclear genes leading to the impairment of mitochondrial respiratory chain or of mitochondrial ATP synthesis has been associated with epileptic phenotypes. Additionally, with a variety of different meth...

conclusions the psychotic symptoms due to temporal lobe epilepsy can be resolved with lamotrigine administration. introduction visual illusions and hallucinations may accompany a wide variety of disorders with many various etiologies; therefore, they are nonspecific phenomena. in a partial seizure, a localized hyper synchronous neuronal discharge evolving into a partial seizure affecting a part...