Mr J.J., a 32-year-old Iraqi presented for investigation of anhidrosis. In 1967 he first developed a pruritic erythroderma with exfoliation, alopecia, nail loss and mucosal ulceration. There was no history of drug ingestion. Recovery was gradual. Since 1968 the patient has been unable to sweat. As a result he is heat intolerant, with 10 min in a hot environment causing palpitation, headache and...

BACKGROUND Congenital insensitivity to pain with anhidrosis is a rare autosomal recessive disorder characterized by hyperpyrexia, anhidrosis, pain insensitivity, self-inflicted injuries, and intellectual disability. The anesthetic management of these patients is challenging owing to the high risk of perioperative complications resulting from their autonomic dysfunction, such as hyperthermia, hy...

BACKGROUND Diffuse alopecia areata or canities subita is a rare variant of alopecia in which hair loss is associated with regrowth of white hairs and possible lightening of the skin. Preferential loss of pigmented hair in this disorder may be related to the melanin pigment system and/or melanocytes. Acquired generalized anhidrosis can be associated with autoimmune disease, cancer, graft-vs-host...

Congenital insensitivity to pain with anhidrosis (CIPA) syndrome is a rare autosomal recessive disease which is also known as hereditary sensory and autonomic neuropathy type 4 (1). The prominent characteristics of the disease include fever due to anhidrosis, absence of sense of pain, painless ulcers in the structures inside the mouth and extremities, self-harm behavior, mild to severe mental r...

influence nerve growth factor synthesis in primary rat astrocytes. Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin diabetic rats: implications for cardiac sympathetic dysinnervation complicating diabetes. Stimulation of nerve growth factor synthesis/ secretion in mouse astroglial cells by coenzymes. A fluorescence-based method for mea...

Introducción: La insensibilidad congénita al dolor con anhidrosis (HSAN-IV o CIPA) es una enfermedad rara sintomatología multisistémica, que impacta el funcionamiento cognitivo, afectando negativamente la calidad de vida los pacientes y sus familias. Se estima mayoría individuos mueren antes tres años por las complicaciones esta genera. Objetivo: Es propósito este articulo realizar revisión clí...

W e present herein data showing for the first time to our knowledge that dry iontophoresis rapidly induces anhidrosis during current application in individuals with hyperhidrosis. This finding provides a novel experimental model for evaluating treatments of hyperhidrosis and determining their mechanism of action. Tap water iontophoresis, during which the patient’s hands are soaked in shallow pa...