Data Synthesis: No trials evaluated screening or monitoring, and 110 evaluated treatments. Angiotensin-converting enzyme inhibitors (relative risk, 0.65 [95% CI, 0.49 to 0.88]) and angiotensin II–receptor blockers (relative risk, 0.77 [CI, 0.66 to 0.90]) reduced end-stage renal disease versus placebo, primarily in patients with diabetes who have macroalbuminuria. Angiotensin-converting enzyme i...

I n this issue of JACC: Heart Failure, Arzt et al. (1) describe the prevalence of sleep-disordered breathing (SDB) in a registry of more than 6,800 patients with chronic stable systolic heart failure (HF) (heart failure with reduced ejection fraction [HFREF]) in Germany. Breathing is moderately or severely abnormal during sleep (apnea-hypopnea index $15) in almost one-half of such patients. Imp...

Submit Manuscript | http://medcraveonline.com Abbreviations: CKD: Chronic Kidney Disease; AKI: Acute Kidney Injury; PE: Pre-Eclampsia; SLE: Systemic Lupus Erythematosus; RA: Rheumatoid Arthritis; SS: Systemic Scleroderma; ESRD: End-Stage Renal Disease; CVDs: Cardiovascular Diseases; GFR: Glomerular Filtration Rate; sCR: Serum Creatinine; LLAC: Lupuslike anticoagulant; PE-AKI: Preeclampsia Acute...

BACKGROUND: Based on a series of clinical trials showing no difference in the effectiveness or tolerability of most major classes of antihypertensive medications, the Joint National Commission on High Blood Pressure Treatment recommends that physicians prescribe β -blockers or diuretics as initial hypertensive therapy unless there are compelling indications for another type of medication. Never...

Submit Manuscript | http://medcraveonline.com Abbreviations: CKD: Chronic Kidney Disease; AKI: Acute Kidney Injury; PE: Pre-Eclampsia; SLE: Systemic Lupus Erythematosus; RA: Rheumatoid Arthritis; SS: Systemic Scleroderma; ESRD: End-Stage Renal Disease; CVDs: Cardiovascular Diseases; GFR: Glomerular Filtration Rate; sCR: Serum Creatinine; LLAC: Lupuslike anticoagulant; PE-AKI: Preeclampsia Acute...

Deposition of β-amyloid in brain is one of the pathological hallmarks of Alzheimer's disease (AD) that is often associated with inflammatory response. Much evidence also points to a link between the renin-angiotensin system, hypertension and dementia. Accordingly, the potential use of anti-inflammatory and antihypertensives might be beneficial agents in AD therapy. In this study, we investigat...